^(99m)Tc(V)-DMSA显像在咽喉部肿瘤诊断中的应用研究  

Evaluation of ^(99m)Tc(V)-DMSA imaging in patients with pharyngolaryngeal carcinoma

作　　者：安锐[1] BenderH GurkeM BiersackHJ 

机构地区：[1]同济医科大学附属协和医院核医学科,武汉430022 [2]联邦德国波恩大学核医学部

出　　处：《临床耳鼻咽喉科杂志》1999年第12期562-564,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的：评价肿瘤阳性显像剂99m锝标记的五价二巯基丁二酸[99mTc（V）－DMSA]在咽喉部肿瘤临床诊断中的应用价值，及其在人体的分布情况。方法：对12例经病理学方法证实为咽喉部肿瘤的患者，进行99mTc（V）-DMSA平面及SPECT断层显像，并对99mTo（V）－DMSA在人体的动态分布进行分析。结果：平面显像有9例11个部位出现放射性异常聚集；SPECT断层显像有11例19个部位有明显的放射性浓聚。此外，5例患者发现远处转移病灶。全身分布实验显示，肾脏的放射性滞留明显高于其他主要脏器。结论：99mTc（V）－DMSA，尤其是采用SPECT断层显像，对咽喉部肿瘤的定位诊断和继发性转移病变（包括局部转移灶和全身转移灶）的寻找具有较高的临床价值。Objective: To evaluate the value of tumor-seeking agent 99mTc(V)-DMSA in patients withpharynglaryngeal carcinoma and its biodistribution in human being. Mathod: Planar and SPECT scintigraphywith 99mTc(V)-DMSA were performed in 12 patients with histologlcally confirmed pharyngolaryngal carcinoma.The dynamic distribution in patients was also analyzed. Result: 9 cases (11 lesions) showed increased uptake byplanar imaging and 11 cases (19 lesions) were clearly demonstrated by SPEC boges. Furthermore, distantmetastatic lesions were showed in 5 patients. Biodistribution in patients showed the accumulation of 99mTc(V)-DMSA in kidney was significantly greater than other organs. Conclusion: These results could suggested the cli-nical utility of 99mTc (V)-DMSA, specially with SPECT, for detecting primary pharynglaryngealcarcinoma andtheir metastatic lesions (both local and distant). 99m Tc(V)-DMSA Tumor-seeking agent Pharyngolaryngal car-cinorna.

关 键 词：放射性核素显像 咽肿瘤 喉肿瘤 

分 类 号：R739.630.4[医药卫生—肿瘤] R739.650.4[医药卫生—临床医学]