灌注-延迟显像方法在兔肝脏VX2肿瘤声学造影中的价值  

Ultrasonographic contrast Perfusion delayed Imaging Method in Diagnosing Rabbit Liver bearing VX2 carcinoma

作　　者：刘政[1] 王红[2] 谢峰[3] 刘梅[2] 

机构地区：[1]重庆市第三军医大学新桥医院超声科,400037 [2]北京军区总医院超声科 [3]北京协和医科大学阜外医院超声科

出　　处：《中国超声医学杂志》1999年第12期892-894,共3页Chinese Journal of Ultrasound in Medicine

摘　　要：目的： 探讨灌注－延迟显像方法在肝脏ＶＸ２ 肿瘤声学造影中的增强效果及变化规律。方法： ９ 只患有ＶＸ２ 肝肿瘤的新西兰白兔经外周静脉注射氟碳声学造影剂， 按常规连续显像方法和灌注－延迟显像方法分别用高频二次谐波显像观察肿瘤造影效果。结果： 灌注－延迟显像产生的视觉肿瘤显影评分显著高于常规二次谐波显像 （Ｐ＜０．０１）， 灌注－延迟显像和常规显像的肿瘤显影视频密度值分别为１１８．３８±１８．４１ 和８７．８３±１７．０３ （Ｐ＜ ０．０１）。常规显像方法和灌注－延迟显像方法在对于 ５－１０ｍ ｍ 肿瘤结节的超声检出率分别为 ６３．６％ 和９０．９％ 。结论： 灌注－延迟显像方法在确保观察到肿瘤血管早期增强现象的同时， 可以显著提高ＶＸ２ 肿瘤声学造影的影像对比度和诊断敏感性。Objective:To assess the value of perfusion delayed(P D) imaging method used as contrast ultrasonography on liver VX2 carcinoma.Methods:Perfluorocarbon filled microbubbles agent was administered to nine VX2 tumor bearing rabbits through ear veins.The animals were studied by perfusion delayed imaging and routine continuous methods(CM) using high frequency second harmonic imaging.Results:Perfusion delayed imaging produced significant visual tumor contrast imaging and higher video intensity tumor contrast than that conventional imaging(118 38±18 41 vs 87 83±17 03).63 6% and 90 0% of the tumors ranging 5 10mm were detected by P D and CM,respectively.Conclusion:Perfusion delayed imaging method produced higher contrast imaging on VX2 tumor than that of the liver mesenchyma,thereby improved the VX2 tumor diagnostic sensitivity.

关 键 词：肝肿瘤 超声波诊断 灌注-延迟显像 

分 类 号：R735.704[医药卫生—肿瘤] R445.1[医药卫生—临床医学]