情感性障碍与单胺氧化酶基因的遗传关联性分析  

Genetic association between mood disorder and monoamine oxidase gene

作　　者：林嗣萃[1] 江三多[1] 江开达[1] 钱伊萍[1] 汪栋祥[1] 汤国梅[1] 吴晓东[1] 顾牛范[1] 任大明[2] 

机构地区：[1]上海市精神卫生中心,200030 [2]上海复旦大学遗传学研究所

出　　处：《中华医学杂志》1999年第12期897-899,共3页National Medical Journal of China

摘　　要：目的　探讨单胺氧化酶 (MAOA)和MAOB型基因多态性与情感性障碍 (双相型和单相型 )间的遗传关联性。方法　应用聚合酶链反应 (PCR)扩增片段长度多态性 (Amp FLP)研究 13 2例情感性障碍患者的MAOA(CA) n,MAOB(GT) n 和MAOB(TG) n 基因座的基因型分布。结果　在 13 2例患者中观察到MAOA(CA) n、MAOB(GT) n 和MAOB(TG) n 基因座的等位基因数目分别为 8、12和 9个 ,片段大小范围为 112～ 12 6bp、168～ 198bp和 195～2 13bp。比较 3个基因座的等位基因的多态性表明 ,患者与正常人间在频率整体分布上差异无显著性意义 (P >0 0 5 ) ,但是 ,MAOB(GT) n 中 180bp和MAOB(TG) n 中 2 0 5bp在 2组中差异有显著意义 (P<0 0 5 )。结论　MAO基因 (A型和B型 )与情感性障碍间无遗传关联性。Objective To ascertain whether the mood disorder (bipolar and unipolar) is genetically associated with genes polymorphisms of MAOA type and MAOB type in the Chinese Methods One hundred and thirty two cases of Chinese with mood disorder were genotyped for the MAOA(CA) n, MAOB(GT) n and MAOB(TG) n locus using Amp FLP Results Among 132 cases with mood disorder, 8 alleles (size: 112 126 bp) of MAOA(CA) n, 12 alleles (size: 168 198 bp) of MOAB(GT) n and 9 alleles (size: 195 213 bp) of MAOB(TG) n locus were observed Comparison of the polymorphisms of all alleles in the three locus showed that no significant difference ( P >0 05) was seen in the frequency distribution between cases with mood disorder (bipolar and unipolar) and controls, but the frequency of 180 bp allele for MAOB(GT) n and 250 bp allele for MAOB(TG) n was significantly different ( P <0 05) between the two groups Conclusion MAO gene (type A and B) is not associated with mood disorder in the Chinese

关 键 词：情感性障碍 单胺氧化酶 基因多态性 遗传关联性 

分 类 号：R749.402[医药卫生—神经病学与精神病学]