nm230-H1、p16抑癌基因蛋白在甲状腺肿瘤中的表达及其临床意义  

The Expression of nm23-H1 and p16 Suppressor Gene Protein in Thyroid Tumor and Clinical Significance

作　　者：李立[1] 丁祖玖[1] 黄裕华 石砳磊 汪漠庆 

机构地区：[1]安徽医科大学病生教研组,合肥230032 [2]安徽巢湖地区医院病理科 [3]解放军105医院病理科 [4]安徽芜湖市一院病理科

出　　处：《肿瘤防治研究》1999年第6期417-419,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨抑癌基因nm23－H1及p16与甲状腺癌的发病学及其生物学行为的关系.方法应用SP免疫组化方法检测了54例甲状腺癌、16例腺癌、10例甲状腺非瘤病变的nm23－H1、p16基因蛋白的表达。结果甲状腺腺瘤及分化型甲状腺癌中的nm23－H1及p16表达率及表达强度均显著增强（P＜0．05），而甲状腺未分化癌中nm23－H1及p16表达率及表达强度则显著降低（P＜0．01）。nm23－H1及p16蛋白表达与甲状腺癌的分化程度呈正相关（P＜0．01），与预淋巴结转移无显著相关性，但nm23－H1与包膜侵犯呈负相关（P＜0．05）。结论nm23－H1及p16基因失活与甲状腺未分化癌的发生密切相关，可为临床判断恶性程度及生物学行为提供参考。Objective To study the relationship between the expression of nm23-H1,p16 protein and thyroid carcinomas Method Immunohistochemistry was used to detect the expression of nu23-H1,p16 protein in 54 thyroid carcinomas ,16 thyroid adenomas ,9 nonneopastic thyroid tissues and 12 adjacent normal tissues Results The expression of nm23-H1 and p16 was much higher in thyroid adenomas and differentiated carcinomas (P＜0.05),wheresas it was much lower in undifferentiated carcinomas (P＜0.01). Positive correlation was observed between the expression of nm23-H1, p16 protein and the degree of differentiation (P＜0.01). There was no significant association betwen the expression of nm23-H1,p16 protein and the cervical lymph node metastasis, but the expression of nm23-H1 was negatively corrated with capsule invasion(P＜0.05). Conclusion The loss of nm23-H1 and p16 function may play an important role in orinogenesis and progress of thyroid undifferentiated careinome. Although the expression of nm23-H1 and p16 can't be used as a marker of low metastatic potential, it may serve as a good marker for the degree of differentiation and biolopcal nehavior .

关 键 词：甲状腺肿瘤 NM23-H1蛋白 P16蛋白 免疫组织化学 

分 类 号：R736.102[医药卫生—肿瘤]