612例鼻咽癌放射治疗预后因素分析  

Prognostic Factors of 612 Patients with Nasopharygeal Carcinoma Treated with Radiotherapy

作　　者：胡国清[1] 肖仁兰[1] 郑祖安[1] 胡长耀[1] 

机构地区：[1]同济医科大学附属同济医院肿瘤科,武汉430030

出　　处：《肿瘤防治研究》1999年第6期459-460,共2页Cancer Research on Prevention and Treatment

摘　　要：目的1973年1月至1987年12月我院共放射治疗鼻咽癌612例，本文对其结果及影响预后的因素予以分析。全组总的5年生存率42．2％。性别、年龄对预后无明显影响，病期、原发肿瘤超胜，预淋巴结转移、颅神经受损和照射剂量是主要的预后因素。随着病期变晚，5年生存率逐渐下降，Ⅰ、Ⅱ期的5年生存率明显高于Ⅲ、Ⅳ期（P＜0．01）。肿瘤局限于鼻咽腔者的预后明显好于超腔者（P＜0．01）。前后组颅神经同时受累预后最差。预淋巴结转移的大小、单双侧、部位、活动或固定对预后有不同的影响。放疗剂量应以65－75Gy／6．5－7．5周为宜。本组资料证明，鼻咽癌放疗失败的主要原因是远处转移与局部复发。Retrospective analysis of 612 patients with nasopharyngeal careinoma (NPC) treated by radiotherapy from Janury, 1973 to December, 1987 was done. The overall 5-year survival rate was 42.2%.Analsis showed that tumor stage, extra-cavitry extension, cervical node metastasis, cranial nerve involvemnt and dosage were the main signifi-cant prognostic factors. Gradual decrease of 5-year survival rate was seen from stage Ⅰ to Ⅳ,The 5-year survival rate was higher in patients with the tumor limited in nasoharynx than those with tumor extending out of nasopharynx (P＜0.01). The invasion of both anterior and posterior cranial never groups was the poorest. The size, region(ipsilateral of bilateral and upper or lower neck) and movability of the metastatic nodes could influence therapeutic results on NPC. The radiation dose ranged from 65-75Gy/6.57. 5W. Distan metastasis and local recurmnce were the main causes of treatent failure.

关 键 词：鼻咽癌 放射疗法 预后 病例分析 

分 类 号：R739.630.5[医药卫生—肿瘤]