乌苯美司联合化疗治疗难治或复发性急性非淋巴细胞白血病临床观察  

Clinical Observation of Ubenimex Combined with Chemotherapy in the Treatment of Refractory or Recurrent Acute Nonlymphocytic Leukemia

作　　者：贺艳娟[1] 赵谢兰[1] 祝焱[1] 李晓林[1] 

机构地区：[1]中南大学湘雅医院血液科,湖南长沙410008

出　　处：《医学临床研究》2010年第12期2234-2236,共3页Journal of Clinical Research

摘　　要：【目的】观察乌苯美司与化疗联合治疗难治或复发性急性非淋巴细胞白血病临床疗效及不良反应。【方法】将24例难治或复发性急性非淋巴细胞白血病患者分为两组，每组12例。治疗组接受含乌苯美司的联合治疗方案，有效者继续服药6～10个月；对照组单用普通联合化疗方案。【结果】治疗组7例达到完全缓解，1例为部分缓解，完全缓解率58．33％，总有效率66．67％。追踪观察1年，7例完全缓解者仅2例在6月个左右复发，且未见明显药物不良反应；对照组4例达到完全缓解，3例为部分缓解，完全缓解率33．33％，总有效率58．33％。追踪观察1年，4例完全缓解者均在1～6个月复发。【结论】乌苯美司能提高化疗药物对急性非淋巴细胞白血病的疗效，延长患者无疾病进展生存期，药物毒性低，值得推广与化疗药物联合应用。[Objective]To observe the clinical efficacy and side effects of ubenimex combined with chemotherapy in the treatment of refractory or recurrent acute nonlymphocytic leukemia. [Methods] Twenty-four patients with refractory or recurrent acute nonlymphocytic leukemia were divided into two groups with 12 cases in each. The treatment group received ubenimex combined with chemotherapy. The patients in the treatment group who had satisfactory effect continued to take medicine for 6 -10 months. The control group received single common combination chemotherapy scheme. [Results] In the treatment group, 7 cases achieved corn plete remission and I case was partial remission, and the complete remission rate and total effective rate were 58.33% and 66.67%, respectively. Two of 7 cases with complete remission recurred within 6 months after 1 year follow up, but no obvious adverse effects were observed. In the control group, 4 cases achieved complete remission and 3 cases were partial remission, and the complete remission rate and total effective rate were 33. 33% and 58.33%, respectively. All the 4 cases with complete remission recurred within 1-6 months after 1- year follow up. [Conclusion] Ubenimex can improve the effect of chemotherapeutic drugs for the treatment of acute nonlymphocytic leukemia, and prolong the survival time without the progression of the disease, and have mild adverse effects. Therefore, it is worthy of being spread and combined with chemotherapeutic drugs.

关 键 词：白血病 非淋巴细胞 急性/药物疗法 亮氨酸/治疗应用 

分 类 号：R733.71[医药卫生—肿瘤]