谷胱甘肽转移酶-π在膀胱癌中的表达及临床意义  

The Expression of glutathiones transferases-π in the tissue of bladder carcinoma

作　　者：齐丽丽[1] 魏若晶[1] 符伟军[2] 王建东 杨文增[1] 

机构地区：[1]河北大学附属医院泌尿外科,河北保定071000 [2]解放军总医院泌尿外科,北京100853 [3]霸州市骨伤科医院,河北廊坊065700

出　　处：《医学研究与教育》2010年第6期47-49,共3页Medical Research and Education

摘　　要：目的研究谷胱甘肽转移酶-π(glutathiones transferases-π,GST-π)在膀胱癌组织中的表达及临床意义。方法用免疫组织化学方法研究147例膀胱癌组织中GST-π的表达情况。结果 GST-π的表达率为52.4%(77/147),在G1级68例中表达率为39.7%(27/68);在G2级49例中表达率为57.1%(28/49);在G3级30例中表达率为73.3%(22/30);117例初发膀胱癌中阳性表达率57.3%(67/117);30例羟喜树碱膀胱内灌注化疗失败的复发膀胱癌中表达率96.7%(29/30)。结论 GST-π的表达水平与膀胱癌的病理分级和恶性度成正相关。Objective To study the relationship between glutathiones transferasesπ（GST-π） expression in bladder cancer and biological behavior.Methods 147 samples of bladder cancer were determined with immunohistochemistry for the expression of GST-π.Results The expression rate of GST-π was 52.4%（77/147）.In the 68 cases with grade Ⅰ the expression rate was 39.7%（27/68）;in 49 cases with grade Ⅱ the expression rate was 57.1%（28/49）;in 30 cases with grade Ⅲ the expression rate was 73.3%（22/30）,in 117 cases with primary bladder cancer the positive expression rate was 57.3%（67/117）,in 30 cases with hydroxycamptothecin intravesical recurrence of bladder cancer chemotherapy the positive expression rate was 96.7%（29/30）.The results show that the level of GST-π expression in bladder cancer,malignant behavior were closely related to pathological grade（P0.05）.Conclusion The results show that the expression of GST-π could reveal the unsuccessful intravesical themotherapy.The expression of GST-π has correlation with the malignant degree and the pathological gradingof bladder cancer.

关 键 词：膀胱癌 谷胱甘肽转移酶-π 诊断 

分 类 号：R73[医药卫生—肿瘤]