普罗布考对非酒精性脂肪性肝病炎性因子表达的影响  

Effect of Probucol on Inflammatory Factors Expression of Non-alcoholic Fatty Liver Disease

作　　者：曾亚[1] 肖云武[2] 

机构地区：[1]湖南省长沙市中心医院,湖南长沙410004 [2]湘潭职业技术学院医学院

出　　处：《实用预防医学》2010年第12期2466-2468,共3页Practical Preventive Medicine

摘　　要：目的探讨普罗布考对非酒精性脂肪性肝病（NAFLD）的治疗作用和机制。方法 64例NAFLD患者按患者就诊顺序编号,依随机数据表分为实验组（n=33）和对照组（n=31）,实验组给予控制饮食和普罗布考治疗3月;对照组给予控制饮食和多种维生素护肝治疗。分别于治疗前后抽血检测空腹血糖（FPG）、血脂和丙氨酸氨基转移酶（ALT）、胰岛素（INS）并计算胰岛素抵抗指数（HOMA-IR）、肿瘤坏死因子-α（TNF-α）、白介素-8、白介素-18（IL-18）,比较各指标治疗前后的差异及治疗后组间差异。结果两组治疗后血酯、ALT较治疗前下降,差异有统计学意义（P〈0.05-0.001）,两组治疗比较,实验组下降更明显（P〈0.05-0.01）;两组治疗后HOMA-IR较治疗前降低,治疗前后比较差异有统计学意义（P〈0.05-0.001）;而治疗组下降更为明显,差异有统计学意义（P〈0.05）;实验组治疗前后TNF-α、IL-8、IL-18比较差异均有统计学意义（P〈0.01-0.001）,治疗后实验组较对照组下降明显,差异有统计学意义（P〈0.01）。结论普罗布考可有效地降低NAFLD的血脂浓度和TNF-α、IL-8、IL-18等炎性因子表达,进而调节肝脏脂肪代谢和改善肝组织炎症坏死,促进肝功能恢复。Objective To observe the effect and mechanism of probucol in non-alcoholic fatty liver disease（NAFLD）. Methods Sixty-four patients with non-alcoholic fatty liver disease were randomized into experimental group（n=33） and control group（n=31）.The patients in experimental group were treated with probucol and diet controlling,while the patients in control group received dietary intervention and multivitamins.The period of treatment was 3 months.FPG,ALT,INS,HOMA-IRI,TNF-α,IL-8,and IL-18 of the patients in two groups were examined before and after the treatment.Results After the treatment,TG,TC,LDL-C,and ALT of the two group were decreased significantly than those before the treatment,and the difference was statistically significant（P〈0.05～0.001）.TG,TC,LDL-C,and ALT of experimental group were declined significantly than those of control group（P〈0.05～0.01）.The HOMA insulin resistance indexes of the two groups were both decreased after three months treatment,there were statistically significant differences between before and after the treatment（P〈0.05～0.001）;the effect was more evident in experimental group than in control group（P〈0.05）.There were statistically significant differences in the levels of TNF-α,IL-8 and IL-18 of experimental group between before and after the treatment（P〈0.01～0.001）.The levels of TNF-α,IL-8 and IL-18 in experimental group and control group were decreased significantly after the treatment（P〈0.01～0.001）,there were statistically significant differences between experimental group and control group（P〈0.01）. Conclusions Probucol can effectively decrease TG,TC,and down-regulate the expression of TNF-α,IL-8,and IL-18 in patient with NAFLD.It is helpful to promote the liver function recovery by modulating liver fat metabolism and inhibiting liver histological activity.

关 键 词：普罗布考 非酒精性脂肪性肝炎 肿瘤坏死因子Α 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统]