利司培酮终止治疗后孤独症患儿行为问题复发的因素  被引量:1

Factors of Relapse for Behavioral Symptoms in Autistic Children after Discontinuing Risperidone

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作  者:韦斌垣 黄飞 覃小田 梁巧琦 

机构地区:[1]南宁残疾儿童康复中心孤独症儿童康复科,南宁530003

出  处:《实用儿科临床杂志》2010年第24期1889-1890,共2页Journal of Applied Clinical Pediatrics

基  金:南宁市科技攻关项目(200802128C)

摘  要:目的探讨在终止利司培酮治疗后,影响孤独症患儿行为问题复发的因素。方法 37例患儿均为2006年3月-2009年10月在本中心接受康复训练,且因行为问题接受利司培酮口服液治疗达8周以上的孤独症患儿。行为问题得到改善后停药,观察患儿在停药6个月内的攻击、自伤、多动及激惹等症状的复发情况,分析孤独症患儿用药前孤独症行为评定量表(ABC)评分、总服药时间、减量时的剂量及总减量时间等因素对复发的影响。结果 37例患儿均随访6个月,在终止利司培酮治疗6个月内,行为问题复发率为27.02%(10/37例),而用药前ABC评分(Wald=1.107,P=0.293)和减量时的剂量(Wald=2.816,P=0.093)二因素对复发无影响,总服药时间(Wald=4.154,P=0.042,OR=0.874)和总减量时间(Wald=4.089,P=0.043,OR=0.726)则对复发有显著影响。结论利司培酮用药时间越长,减量速度越慢,终止治疗后孤独症患儿行为问题复发的概率就越低。Objective To explore the factors of relapse for behavioral symptoms in autistic children after discontinuing risperidone.Methods Thirty seven autistic children were selected who were rehabilitation in hospital for behavioral symptoms from Mar.2006 to Oct.2009,improved behavioral symptoms with being treated by risperidone oral solution for more than 8 weeks.All cases were discontinued for behavioral symptoms improved and observed relapse of behavioral symptoms such as aggression,self-injurious,hyperactivity and tantrums after discontinuing risperidone within 6 months,then it was analyzed the relapse of affection for the pretherapy scores of autism behavior checklist(ABC),total time of taking medicine,dosage of reduction,and total time of extenuation in all children.Results Thirty-seven cases were all followed-up for 6 months after discontinuing.The relapse rate of behavioral symptoms was 27.02%(10/37 cases) after discontinuing risperidone within 6 months,and there were significant difference to affect the relapse for the total time of taking medicine(Wald=4.154,P=0.042,OR=0.874)and total time of extenuation(Wald=4.089,P=0.043,OR=0.726),but not for the pretherapy scores of ABC(Wald=1.107,P=0.293) and dosage of reduction(Wald=2.816,P=0.093).Conclusions The longer risperidone is taken and the lower risperidone is reducted,the lower it would be for the probability of relapse of behavioral symptoms with autistic children after discontinuing risperidone.

关 键 词:孤独症 利司培酮 复发 儿童 

分 类 号:R749.94[医药卫生—神经病学与精神病学]

 

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