前列腺导管腺癌1例报告并文献复习  

Ductal Adenocarcinoma of the Prostate(A Case Report and Literature Review)

作　　者：陈靖[1] 罗子靖[1] 权昌益[1] 蒋宁[1] 李博[1] 常文亮[1] 王江[1] 景宝[1] 温思盟[1] 刘志虎[1] 郝海峰[1] 牛远杰[1] 

机构地区：[1]天津医科大学第二医院泌尿外科 天津市泌尿外科研究所,天津300211

出　　处：《临床泌尿外科杂志》2011年第2期135-137,共3页Journal of Clinical Urology

摘　　要：目的:探讨前列腺导管腺癌的临床表现、病理特征、治疗方法等。方法:报告1例前列腺导管腺癌疾病的情况,并结合文献对之诊断治疗行进一步探讨。1例82岁男性患者主因"尿频、尿急7年,加重3个月"入院,误诊为其他疾病。血清总PSA为2.38μg/L,行TURP后方明确诊断。后行根治切除和相应药物治疗等。结果:病理报告:前列腺导管腺癌,Gleason 8分。免疫组化染色PSA(+),前列腺酸性磷酸酶(PAP)(+).低分子角蛋白(CKAE)(+),高分子角蛋白(CKHW)(+).雄激素受体(AR)(—)。患者术后恢复可,长期疗效需进一步随访。结论:前列腺导管腺癌在前列腺癌中罕见,难于早期诊断,确诊主要依靠病理和免疫组化检查,治疗方法可采用根治性前列腺切除术。Objective：To evaluate the clinical and pathological characteristics and treatment of Duetal Adeno carcinoma of the Prostate. Methods：A case of Ductal Adenocareinoma of the Prostate gland was reported, and the relevant literature was reviewed to investigated the diagnosis and treatment of this disease. A 82 year old male suffered from ＂frequency, urgency, 7 years, increased for 3 months＂ misdiagnosis of patients. His serum prostatic specific antigen（PSA）level was 2. 38 μg/L. After TURP, the diagnosis is clear. Then radical prostatectomy and other treatment such as drug treatment was performed on him. Results：The postoperative pathology showed a primary Ductal Adenocarcinorna. Gleason score was 8. With immunohistochemical staining, the tumor cells were positire for PSA, PAP （prostatic acid phosphatase） ,CKAE and CKHW, but negative for androgen receptor. Postoperatively, the patient recovered fairishly but long term effects need further follow-up. Conclusions： Ductal Adenocarcinorna of the Prostate is a clinically rare subtype of prostate cancer and difficult to be found in early stage. The diagnosis depends on histopathologic and imrnunohistochernical studies. Radical prostatectomy is recommended for this disease.

关 键 词：前列腺癌 导管腺癌 免疫组化 组织病理 

分 类 号：R737.25[医药卫生—肿瘤]