DKK3和SFRP2基因甲基化在肿瘤中的研究进展  

The progresses of DKK3 and SFRP2 gene methylation in neoplasm

作　　者：赵玉凤[1] 李锋[1] 付欣鸽[2] 曹玉文[1] 

机构地区：[1]石河子大学医学院病理学教研室,新疆石河子832002 [2]广东省中医院病理科,广东广州510120

出　　处：《农垦医学》2010年第4期348-352,共5页Journal of Nongken Medicine

基　　金：国家自然科学基金(30760072)

摘　　要：DKK3和SFRP2基因是W nt信号传导通路中的抑癌基因,其启动子区CpG岛的甲基化与乳腺癌、肠癌、肺癌、肝癌等许多恶性肿瘤的发生、发展密切相关,在恶性肿瘤中甲基化或高甲基化,在癌旁组织或正常组织中无甲基化或低甲基化,并且甲基化导致其基因表达明显下调。DKK3 and SFRP2 gene were the suppressor genes in the Wnt signaling pathway.Their promoter CpG islands methylation were closely related to occurrence and development of breast cancer,colon cancer,lung cancer,liver cancer and other malignant tumor.It was methylated or hypermethylated in cancer tissue,no methylation or low methylation in adjacent cancer tissue and normal tissue.The expression genes with methylation were significantly reduced.

关 键 词：甲基化 肿瘤 DKK3 SFRP2 

分 类 号：Q75[生物学—分子生物学] R730[医药卫生—肿瘤]