晚发型单相抑郁症遗传方式的研究  

A study of genetic model in late onset unipolar depression

作　　者：蒋德珍[1] 董小惠[1] 崔风伟[1] 祝妞妞[1] 潘乾洪 祁曙光[1] 

机构地区：[1]无锡市精神卫生中心精神科,214151

出　　处：《神经疾病与精神卫生》2010年第6期572-574,共3页Journal of Neuroscience and Mental Health

摘　　要：目的 探讨晚发型单相抑郁症的遗传实方式.方法 采用严格的纳入标准,对符合中国精神疾病分类方案与诊断标准第3版（CCMD-3）抑郁发作诊断标准,首次发病年龄＞30岁的68例单相抑郁症患者用医学遗传数学方法中分离分析和多基因阈值理论进行遗传实方式的研究.结果 晚发型一级亲属单相抑郁症加权平均遗传率及标准误为（75.7±1.2）%,预期发病率为5.0%,与实际发病率3.6 %相比较无显著性差异（u=1.5,P＞0.05）.结论 晚发型单相抑郁症的遗传方式符合多基因遗传.Objective To investigate the mode of inheritance of late onset unipolar depression. Methods Sixty--eight subjects who met CCMD--3 diagnostic criteria for depressive episode which begin after 30 years old and their family were studied using segregation analysis and polygenic threshold theory. Results The weighted mean of the heritability and standard error was（75.7±1.2）. The expected in- cidence was 5.0% which was not significantly different from the incidence of 3.6% in their first-degree relatives. Conclusions The results suggest that the mode of inheritance of late onset unipolar de pression was in conformity to multifactorial inheritance.

关 键 词：晚发型 单相抑郁症 遗传方式 

分 类 号：R749.4[医药卫生—神经病学与精神病学]