PET在原发性肝癌中的应用进展  

The Application of PET in Hepatocellular Carcinoma

作　　者：周嘉敏[1] 王鲁[1] 石洪成[1] 

机构地区：[1]复旦大学附属中山医院肝癌研究所,上海200032

出　　处：《医学研究杂志》2011年第1期139-143,共5页Journal of Medical Research

基　　金：上海市曙光计划资助项目(07SG04)

摘　　要：正电子发射体层摄影(position emission tomography,PET)作为一种新型的影像学检查技术,由于其分子水平上的功能成像特征,正在原发性肝癌(主要为肝细胞癌,以下简称肝癌)的诊断、预后及疗效判断方面发挥越来越重要的作用。联合应用多种示踪剂可以提高PET检查对肝癌诊断的灵敏度和特异度;通过研究肝癌细胞糖酵解途径的关键分子,发现18F-FDG的摄取模式与肝癌转移复发的生物学特性密切相关,且该摄取模式能有效预测非手术治疗患者的预后;而肝移植术前PET能够成为肝癌肝移植合适候选者的重要筛选指标。As a new imaging technique,PET is more and more important in diagnosis,prognosis and therapeutic effect judgement of hepatocellular carcinoma for its functional imaging based on the molecular level.Present studies demonstrate that multi-tracer agents combined imaging may promote the sensibility and specificity of the hepatocellular carcinoma diagnosis,and also reveal the closing relationship between cancer cell biocharacteristics and 18F-FDG SUV through researching the key molecule of the glucolysis pathway in hepatoma cell.The great advantage of PET in the prediction of tumor recurrence and metastasis is shown as well.Furthermore,PET can be an important selection factor of adequate candidates for liver transplantation.This is the review focusing on the role of PET in hepatocellular cacinoma.

关 键 词：原发性肝癌 PET 18F-FDG 

分 类 号：R735.7[医药卫生—肿瘤]