肾素基因G10631A多态性与脑梗死的关系  

The Relationship between G10631A Polymorphism in the Renin Gene and Cerebral Infarction

作　　者：孙洪英[1] 和姬苓[1] 杨国安[1] 袁利和[2] 杨月明[2] 张佳[1] 

机构地区：[1]包头医学院第一附属医院,内蒙古包头014010 [2]包钢医院

出　　处：《包头医学院学报》2010年第6期5-6,共2页Journal of Baotou Medical College

基　　金：内蒙古自治区人事厅人才开发基金资助项目

摘　　要：目的:研究肾素(REN)基因G10631A单核苷酸多态性与脑梗死的关系。方法:采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法对82例脑梗死患者和89例正常对照进行了基因分型。结果:脑梗死组REN10631位点AA基因型和A等位基因频率均显著高于正常对照组,差异具有统计学意义(P<0.05)。结论:REN 10631位点AA基因型和A等位基因可能为脑梗死的易患因素。Objective： To investigate the relationship between G10631A polymorphism in the renin gene and cerebral infaretion. Methods： The polymorphism was genotyped among 82 cases and 89 controls by polymerase chain reaction - restriction fragment length polymorphism （PCR - RFLP）. Results： The frequencies of AA genotype and A allele in cases were significantly higher than in controls （ P 〈0.05）. Conclusion： The AA genotype and A allele of G10631A polymorphism in the renin gene might be susceptibility factors for cerebral infarction.

关 键 词：脑梗死 肾素 基因多态性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]