诱导性多能干细胞及其在脑血管病研究和治疗中的应用  

Induced pluripotent stem cells and their application in research and treatment of cerebrovascular disease

作　　者：廖伟[1] 汪泱[2] 邓志锋[1] 

机构地区：[1]南昌大学第二附属医院神经外科,330006 [2]南昌大学泌尿外科研究所,330006

出　　处：《国际脑血管病杂志》2010年第11期860-864,共5页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金（30960396）

摘　　要：诱导性多能干（induced pluripotent stem,iPS）细胞由已分化的体细胞重新编程而来,在生物学特性方面与胚胎干细胞极其相似.与胚胎干细胞相比,iPS细胞不受细胞来源、免疫排斥和伦理学等方面的限制,并具有保留特定个体基因等优势,为再生医学以及组织工程等领域提供了可能的细胞资源.文章主要介绍了iPS细胞及其在脑血管病研究和治疗中的应用.Induced pluripotent stem （iPS） cells are reprogrammed by the differentiated adult cells, ard in terms of biological characteristics they are remarkably similar to embryonic stem cells. Compared to the embryonic stem cells, the iPS cells are unrestricted by cell resources, immune rejection and ethics, They maintain the advantages such as specific individual genes, and provide potential cell resources for the fields of regenerative medicine and tissue engineering, This article mainly introduces the iPS cells and their application in the research and treatment of cerebrovascular diseases.

关 键 词：多功能干细胞 核程序重排 细胞分化 神经元 脑血管障碍 细胞移植 

分 类 号：R74[医药卫生—神经病学与精神病学]