梗阻性黄疸对大鼠小肠功能的影响研究  

The effect of obstructive jaundice on small intestinal function in rats

作　　者：王向东[1] 廖群纷[1] 

机构地区：[1]四川省科学城医院,四川绵阳621900

出　　处：《西部医学》2011年第2期232-233,共2页Medical Journal of West China

摘　　要：目的探讨梗阻性黄疸对大鼠小肠功能的影响。方法成年雌性SD大鼠共80只随机分为两组:模型组(40只),对照组(40只)。模型组结扎胆总管。对照组为假手术组。每组分为三个小组,分别用作测血糖、血脂和葡聚糖蓝推进率。术后第4天开始禁食24小时,于第5天测血糖(GLU)、总胆固醇(TC)、甘油三脂(TG)、然后分别用50%的葡萄糖,30%的脂肪乳和葡聚糖蓝灌胃,并分别于半小时后测血糖和葡聚糖蓝推进率,于2小时后测总胆固醇、甘油三脂。结果模型组小肠葡聚糖蓝推进率明显低于对照组(P<0.05),灌胃后血糖和甘油三脂水平也明显低于对照组(P<0.05)。结论梗阻性黄疸影响大鼠小肠的吸收能力和蠕动功能。Objective To explore the effect of obstructive jaundice on small intestinal function in rats.Methods 80 female SD rats were randomly divided into two groups,including the model group（ligation of the bile duct） and control group（sham-operation）.In both groups,the serumlevels of TC,TG and GLU were assayed before and after intmgastric administration of 30% intralipidand 50% glucose.The gut transits were measured in vivo after intragastric administration of blue dextra.Results Compared with control group,the gut transits decreased significantly in model group（P0.05）,the serum levels of TG and GLU also decreased significantlyn model group（P0.05）.Conclusion Obstructive jaundice has negative effects on the absorption capacity and peristalsis of small intestinal in rats.

关 键 词：大鼠 梗阻性黄疸 肠道功能 

分 类 号：R-33[医药卫生] R657.43