2型糖尿病伴发胆囊结石的临床研究  

Clinical study on type 2 diabetes mellitus with gallstone

作　　者：何丽[1] 李清楚[1] 

机构地区：[1]郑州市中心医院内分泌科,450007

出　　处：《中国实用医刊》2011年第4期41-42,共2页Chinese Journal of Practical Medicine

摘　　要：目的通过测定2型糖尿病伴发胆囊结石患者的血脂，探讨糖尿病患者伴发胆囊结石的影响因素。方法所有受试者按伴不伴发胆囊结石分为两组：2型糖尿病伴发胆囊结石组（试验组），2型糖尿病不伴发胆囊结石组（对照组）。空腹抽血查总胆固醇（TCH）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、甘油三酯（TG）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）、血糖、胰岛素，并计算胰岛素抵抗指数，进行组间对比，分析2型糖尿病伴发胆囊结石的危险因素。结果2型糖尿病伴发胆囊结石组的病程、空腹胰岛素水平、胰岛素抵抗指数、HDL—C、LDL—C、ApoA1、ApoB与对照组比较差异均有统计学意义（P均〈0．05）。结论2型糖尿病患者胆囊结石的发生和胰岛素抵抗有关，也与LDL—C、ApoB升高，HDL～C、ApoA1降低有关。降血脂治疗对预防胆囊结石的发生是否有一定的作用．仍需进一步的研究。Objective Through determined serum lipids of type 2 diabetes mellitus with gallstone, and to discuss the effect factors of gallstone in diabetic patients. Methods All cases were divided into two groups： type 2 diabetes mellitus with gallstone （tests group） and type 2 diabetes mellitus without gallstone（control group）. We defected the levels of serum lipids, glucose, insulin and evaluating insulin resistance index （ HOMA - IR） to discuss the high - risk factors of gallstone in diabetic patients. Results The levels of insulin, HOMA - IR, HDL - C, LDL - C, ApoA1 and ApoB were significant different in the two groups （P 〈 0.05 ）. Conclusions There are relations between insulin resistance and gallstone in type 2 diabetes mellitus. Gallstone maybe related to ascendant of LDL - C and ApoB, and to decreased HDL - C and ApoAl. There is no report of deceased lipid which maybe play a role in preventing the development of gallstone. We must to study farther.

关 键 词：糖尿病 胆囊结石 血脂 

分 类 号：R575[医药卫生—消化系统] R587[医药卫生—内科学]