同型半胱氨酸、高敏C-反应蛋白与急性脑梗死患者颈动脉粥样硬化的相关性研究  

Relationship of Hcy and hs - CRP with carotid atherosclerosis in patients with acute ceretrai infarction

作　　者：闫斌[1] 郭金涛[1] 刘乐喜[1] 郭雅聪[1] 刘远洪[1] 李照凯[1] 

机构地区：[1]河南省濮阳市人民医院神经内科,457000

出　　处：《中国实用医刊》2011年第4期50-52,共3页Chinese Journal of Practical Medicine

摘　　要：目的 探讨急性脑梗死患者颈动脉粥样硬化与同型半胱氨酸（Hcy）、高敏c-反应蛋白（hs—CRP）的相关性。方法对190例急性脑梗死患者和110例健康体检者均进行颈动脉彩超多普勒检查，测量颈动脉内中膜厚度（IMT），观察有无颈动脉斑块形成，同时进行Hcy、hs—CRP、糖化血红蛋白（HbA1C）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—c）浓度测定。结果脑梗死组Hcy、hs—CRP水平明显高于正常对照组（健康体检者），两组浓度间比较差异有统计学意义（P〈0．01）；根据颈动脉有无斑块将脑梗死组分为两个亚组：有斑块组、无斑块组，脑梗死有斑块组Hcy、hs—CRP浓度明显高于脑梗死无斑块组，两组浓度闻比较差异有统计学意义（P〈0．01）。Hcy、hs—CRP升高具有一致性。结论Hcy、hs—CRP与急性脑梗死患者颈动脉粥样硬化的发生、发展有一定的相关性，炎症反应参与了脑梗死患者颈动脉粥样硬化的形成，且Hcv、hs—CRP之间亦有一定的相关性。Objective To investigate and analyze the relationship between high sensitivity C - reactive protein （hs -CRP）, homocysteine（Hcy） and carotid atherosclerosis in patients with acute cerebral infarction. Methods One hundred and ninety cases of acute cerebral infarction were assigned as experimental group and one hundred and ten healthy people as control group. The changes of carotid intimal - medial thickness （IMT） were examind by carotid duplex uhrasonography scanning. The levels of hs- CRP and Hcy were measured. Glycated hemoglobin （HbAlc） , total cholesterol （TC） and low - density lipoprotein （LDL） were measured routinely. Results The levels of serum hs - CRP, plasma homocysteine were significantly increased in the experimental group compared to the control group （ P 〈0. 01）. Furthermore, the levels of serum hs- CRP, plasma homocysteine were also significantly in- creased in the experimental group with plaques compared to the experimental group with noplaques （P 〈 0.01 ）. The hs - CRP level was associated with the Hcy level. Conclusions The levels of serum hs - CRP and Hcy in acute cerebral infarction patients with carotid atherosclerosis increase significantly. Inflammatory rection brings carotid atherosclerosis in cerebral infarction.

关 键 词：颈动脉粥样硬化 脑梗死 高敏C-反应蛋白 同型半胱氨酸 

分 类 号：R74[医药卫生—神经病学与精神病学]