KI-67、凋亡指数与新疆维吾尔族、汉族宫颈癌新辅助化疗疗效的相关性研究  

Expressions and significance of Ki-67 and apoptosis index in cervical carcinoma in Xinjiang Uigur and Han patients before and after neoadjuvant chemotherapy

作　　者：徐跃勋[1] 王英红[2] 

机构地区：[1]新疆石河子大学医学院 [2]新疆石河子大学医学院一附院妇产科,新疆石河子832002

出　　处：《临床和实验医学杂志》2011年第3期167-169,共3页Journal of Clinical and Experimental Medicine

基　　金：石河子大学重大攻关项目(gxji2008-zdgg07)

摘　　要：目的探讨维吾尔族(维族)、汉族宫颈鳞癌组织细胞增殖和凋亡与新辅助化疗疗效的关系及民族之间的差异。方法选取维、汉族正常宫颈组分别20、11例作为对照组;维、汉新辅助化疗前后的宫颈癌组织分别22、30例。分别应用免疫组化SP法和脱氧核糖核苷酸末端转移酶介导dUTP缺口末端标记法(TUNEL)检测组织中的Ki-67核抗原指数(PI)和凋亡指数(AI)。结果新辅助化疗取得了很好的临床疗效,维、汉族化疗前宫颈鳞癌组织Ki-67增殖指数维族高于汉族(P>0.05),化疗后均下降,汉族下降程度较维族高(P<0.05);维、汉之间化疗前凋亡指数汉族较维族高(P>0.05);化疗后汉族高于维族(P<0.05)。结论新辅助化疗近期疗效肯定,不仅可有效抑制宫颈癌细胞增殖,而且能够诱导细胞凋亡,维、汉民族之间存在差异,汉族在化疗疗效上较维族更敏感。Objective To investigate cell proliferation and apoptosis in cervical squamous cell carcinoma and their relation to the therapeutic effect of neoadjuvant chemotherapy in the Uygur and Han people.Methods Twenty-two Uigur cases and 30 Han cases of cervical cancer treated with neoadjuvant chemotherapy were included in this study.Twenty Uigur women and 11 Han women without cancer were used as control.Tissue nuclear antigen Ki-67 index（PI） and apoptosis index（AI） were detected by SP immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling（TUNEL）.Results Neoadjuvant chemotherapy achieved good clinical efficacy,Ki-67 was higher in Uigur patients than Han patients（P0.05） in cervical squamous cell carcinoma before chemotherapy.Ki-67 decreased in both Han and Uigur patients after chemotherapy,but the decrease was more obvious in Han patients than Uigur patients（P0.05）.AI was higher in Han patients than Uigur patients in cervical squamous cell carcinoma before chemotherapy,but the difference was not significant（P0.05）.After chemotherapy,AI was still higher in Han patients than Uigur patients（P0.05）.Conclusion Neoadjuvant chemotherapy may inhibit cancer cell proliferation and induce apoptosis.Han patients with cervical carcinoma are more sensitive to neoadjuvant chemotherapy.

关 键 词：宫颈癌 汉族 维族 KI-67核抗原 凋亡指数 新辅助化疗 

分 类 号：R737.33[医药卫生—肿瘤]