雌孕激素替代治疗对特纳综合征患者骨密度的影响  

Effects of long-term combined estradiol and progesterone therapy on bone mineral density in patients with Turner syndrome

作　　者：胡玲[1] 秦洁[1] 雷崐[1] 杨平安[1] 茅江峰[2] 

机构地区：[1]山西省人民医院内分泌科,太原030012 [2]中国医学科学院北京协和医学院北京协和医院内分泌科

出　　处：《中华全科医师杂志》2011年第2期133-135,共3页Chinese Journal of General Practitioners

摘　　要：对8例特纳综合征患者进行6年的雌孕激素补充治疗，比较治疗前后骨密度的变化。治疗前患者的骨密度明显低于同龄同性别的正常水平。经过6年性激素治疗后，患者的骨密度略有增加，但仍显著低于同龄同性别的正常水平。第2～4腰椎的骨密度从（0．75±0．12）g／cm^2增加到（0．84±0．22）g／cm^2，同龄同性别的z评分从-3．2±0．9升高到-2．2±0．6。髋部总体的骨密度从（0．68±0．07）g/cm^2增加到（0．81±0．08）g／cm^2，Z评分从-2．2±0．5增加到-1．2±0．3。长期雌孕激素补充治疗，可改善特纳综合征患者的骨密度，但不能使骨密度恢复到正常水平。The purpose of this study was to investigate the effects of long-term estradiol and progesterone combined therapy on bone mineral density （ BMD ） in patients with Turner syndrome. Eight patients with Turner syndrome received estradiol and progesterone combined therapy for six years were observed and BMD was measured for each of them before hormone replacement therapy （HRT） and at an interval of one to two years after HRT and compared with that in normal age-sex matched women. BMD was significantly lower in patients with Turner syndrome than that in normal controls before HRT. All the patients with Turner syndrome had breast enlargement and irregular vaginal bleeding after HRT. BMD increased slightly in the patients with Turner syndrome after six-year HRT , but still much lower than that in normal controls. Their BMD of the 2nd to 4th lumbar vertebra increased to （ 0. 84± 0. 22 ） g/cm2 after HRT from （0. 75 ±0. 12） g/cm2 before it, with Z-score increased to -2. 2 ±0. 6 from -3.2 ±0. 9, respectively; and overall BMD of the hip increased to （0. 81±0. 08） g/cm2 after HRT from （0. 68 ±0. 07） g/cm2 before it, with Z-score increased to - 1.2 ±0. 3 from - 2. 2 ± 0. 5, respectively. Long-term HRT can improve their BMD for patients with Turner syndrome but can not restore it to normal.

关 键 词：特纳综合征 骨密度 

分 类 号：R596[医药卫生—内科学]