高分子前药研究进展  

Research Progress of Polymeric Prodrugs

作　　者：王君莲[1] 郝红[1] 王扬[1] 石梅[1] 

机构地区：[1]西北大学化工学院,西安710069

出　　处：《化学通报》2011年第2期131-136,共6页Chemistry

基　　金：人事部留学人员科技活动择优项目(SLZ2009011);陕西省13115科技创新工程重大科技专项项目(2007ZDKG-50)资助

摘　　要：高分子前药可以控制药物释放速度,降低小分子药物的毒副作用,减少抗药性,增强抗肿瘤药物的靶向性和选择性,提高多肽、蛋白质和核酸类药物的稳定性和有效利用率,引起国内外广泛关注。本文综述了近年来高分子药物的研究进展,主要从高分子载体材料的选择与改性对载药量、生物相容性和肾排泄的影响,以及化学合成过程中载体和药物末端的修饰、空间位阻的减小、特异性靶向配体的引入等方面做了论述。探讨了高分子前药领域的研究前景和所面临的问题。Polymeric prodrugs have been drawing attention because they can control drug release,reduce systemic toxicity of low molecular weight drugs,improve targeting and selective of antineoplastic drugs,and enhance stability and bioavailability of peptides,proteins and oligonucleotides.The recent advance of polymeric prodrugs,including the effect of polymeric carrier material on the drug loading,biocompatibility and renal excretion were reviewed.In addition,the methods about the terminal group modification of carriers and drugs,reduction of steric hindrance,specific targeting ligands in chemical synthesis were discussed,too.Finally,the research prospects and issues faced in this field were pointed out.

关 键 词：高分子 载体 前药 药物控释 

分 类 号：R914.5[医药卫生—药物化学]