膀胱尿路上皮癌组织中HMGA2蛋白表达及其临床意义  

Expression and clinical significance of HMGA2 protein in urothelial bladder cancer

作　　者：杨国良[1] 张连华[1] 薄隽杰[1] 侯恺林[1] 朱寅杰[1] 张超[1] 蒋海锋[1] 刘东明[1] 黄翼然[1] 

机构地区：[1]上海交通大学医学院附属仁济医院泌尿外科,200001

出　　处：《中华泌尿外科杂志》2011年第2期115-118,共4页Chinese Journal of Urology

基　　金：基金项目：上海市科委自然基金（09ZR14180000）

摘　　要：目的探讨高迁移率族蛋白A2（highmobilitygroupproteinA2，HMGA2）在膀胱癌组织中的表达情况，并分析其与临床病理特征及复发的关系。方法膀胱尿路上皮癌标本148例，正常膀胱组织标本30例，采用免疫组织化学方法检测2组标本组织中HMGA2蛋白的表达，并结合临床资料进行分析。结果正常膀胱组织中无HMGA2蛋白表达，肿瘤组织中随病理分级和分期增加，HMGA2蛋白相对表达量逐渐增高。HMGA2蛋白在G1、G2、G3组织中表达阳性率分别为21．3％、60．3％、82．1％，差异有统计学意义（P〈0．001）。非肌层浸润性膀胱尿路上皮癌和肌层浸润性膀胱尿路上皮癌中HMGA2蛋白表达的阳性率分别为43．3％和72．7％，差异有统计学意义（p=0．003）。随访2～95个月，复发64例，复发组与未复发组中HMGA2蛋白表达阳性率分别为54．7％和25．0％，差异有统计学意义（P=0．007）。结论HMGA2蛋白表达在膀胱癌组织中明显高于正常组织，HMGA2蛋白表达与膀胱癌的分级、分期、复发有关；与患者年龄、性别、肿瘤数目无相关性。检测HMGA2蛋白有助于膀胱癌的诊断及预后的评估。Objective This study was to explore the expression and significance of HMA2 in bladder cancer , analyze its correlations to clinicopathologic and recurrence of bladder cancer. Meth- ods The expression of HMGA2 protein in 148 specimens of bladder cancer and 30 specimens of nor- mal bladder tissues was detected by immunohistoehemtry, its correlations to clinieopathologie features was analyzed. Results There was no expression of HMGA2 protein in normal bladder tissues, while the expression level of HMGA2 protein was getting higher with the increase of tumor pathology grade and stage. The positive rate of HMGA2 protein was 21.3~ in G1 bladder cancer, 60.3% in G2 bladder cancer, 82.1% in G3 bladder cancer, its difference is significant （P〈0. 001）. It was signifi cantly lower in non-muscle invasive bladder cancer than in muscle invasive bladder cancer （43.3% vs 72.7%, P=0. 003）. The patients were followed up for 2~95 months, patients of recurrence was 64, HMGA2 protein expression was significantly higher in patients with recurrence than with non recur rence （54.7% vs 25.0%, P =0. 007）. Conclusions The expression of HMGA2 protein was highly in bladder cancer, the positive rate of HMGA2 protein expression was related with classification, TMN stage and recurrence, but not with sex, age, tumor number （P〉0. 05）. The detection of the expression of HMGA2 protein is in favor of diagnosis and prognostic evaluation of bladder cancer.

关 键 词：膀胱肿瘤 高迁移率族蛋白A2 免疫组化 诊断 预后 

分 类 号：R737.14[医药卫生—肿瘤]