羟基磷灰石-阿霉素复合物对大鼠肝移植性肿瘤局部切除术后治疗作用的研究  

Curative effects of hydroxyapatite adriamycin (HAP ADM) complexes on liver implanted tumors after local excision in rats

作　　者：夏清华[1] 陈道达[1] 张建平[1] 陈先祥[1] 

机构地区：[1]同济医科大学附属协和医院普外科

出　　处：《中华普通外科杂志》1999年第3期179-181,共3页Chinese Journal of General Surgery

摘　　要：目的探讨大鼠肝移植性肿瘤局部切除术后，局部埋置抗癌复合物羟基磷灰石阿霉素对大鼠存活、肿瘤复发和肝功能的影响。方法制作大鼠Ｗ２５６癌肉瘤肝移植瘤模型。肿瘤局部切除后，各组大鼠分别于肝创缘埋置羟基磷灰石阿霉素（Ａ组）；注射阿霉素水溶液（Ｂ组）和注射生理盐水（Ｃ组）。测定各组大鼠术后１、３、７天的肝功能。观察术后３个月大鼠死亡和肿瘤复发情况。结果Ａ组大鼠术后死亡率（２５％，３／１２）及复发率（３３％，４／１２）均较Ｃ组（８３％，１０／１２和９２％，１１／１２）明显下降（Ｐ＜００１），而复发率（３３％，４／１２）亦较Ｂ组（７５％，９／１２）降低（Ｐ＜００５），并且肝功能受损亦较Ｂ组减轻（Ｐ＜００５或Ｐ＜００１）。结论羟基磷灰石阿霉素复合物局部埋置，提高了肝移植瘤大鼠局部切除术后的生存率，降低了肿瘤的复发率，对肝功能损害较轻，有一定的临床意义。Objectives To evaluate the effects of locally implanted HAP ADM complex on the survival,tumor recurrence and liver function of rats undergoing local excision of implanted liver tumors.Methods Wistar rat model was made by local resection of the implanted W 256 carcinosarcoma within the left lobe when the foci grew up to a size of about 1 cm in diameter.Rats were randomly divided into 3 group with HAP ADM complex injection (group A),ADM injection (group B), and normal solution (group C) into the edges of the liver parenchyma respectively.The hepatic function at 1st,3rd,and 7th day,the martality and tumor recurrence of the rats within 3 months were abserved. Results The mortality (25%,3/12) and the recurrence rate (33%,4/12) in group A were lower than that of group C (83%,10/12 and 92%, 11/12, P <0 01),and the recurrence rate (33%, 4/12) was lower than that of group B ( 75%,9/12, P <0 05), the hepatic function test was less serious than that of group B ( P <0 05).Conclusions The slow releasing effect of ADM in the HAP ADM complex may explain the better clinical result in this study and its clinical implication need to be futher evaluated.

关 键 词：肝肿瘤 动物实验 抗癌药 羟基磷灰石 阿霉素 

分 类 号：R735.705[医药卫生—肿瘤] R73-36[医药卫生—临床医学]