Survivin、COX-2和bFGF在乳腺癌组织中的表达及相关性的探讨  

Expression and relationship of Survivin,cyclooxgenase-2(COX-2) and basic fibroblast growth factor(bFGF) in normal breast epithelia,benign breast disease and breast cancer

作　　者：周围[1] 周恩相 王泽强[1] 陈洲熙[1] 郭琼[1] 廖妮[1] 丁祖炎 

机构地区：[1]湖南省株洲市一医院乳腺外科,湖南株州412000 [2]湖南湘雅二医院乳腺甲状腺外科,湖南长沙410011 [3]湖南省株州市一医院病理科,湖南株州412000

出　　处：《现代肿瘤医学》2011年第2期279-283,共5页Journal of Modern Oncology

摘　　要：目的:研究抗凋亡基因(Survivin)、环氧化酶-2(COX-2)和碱性成纤维细胞生长因子(bFGF)在正常乳腺组织、乳腺良性疾病和乳腺癌组织中的表达及其相关性。方法:用免疫组化方法检测10例正常乳腺组织、45例乳腺良性疾病和60例乳腺癌中Survivin、COX-2和bFGF的表达,并分析其与乳腺癌的临床病理特征的相关性。结果:Survivin、COX-2和bFGF在良性乳腺疾病及与乳腺癌组织中的表达相比均有显著差异。Survivin、Cox-2和bFGF的表达都与乳腺癌淋巴结转移和TNM病理分期显著相关。结论:Survivin、COX-2在乳腺癌中的表达明显高于正常乳腺和良性乳腺疾病。bFGF在乳腺癌中的表达高于良性乳腺疾病。Sur-vivin、COX-2和bFGF可能在乳腺癌的发生、生长和转移中起重要作用,其中COX-2和bFGF可能起协同作用,而Survivin则是三者中相对独立的一种因子。Objective：To study the expression of Survivin, cyclooxgenase - 2 （COX -2） and basic fibroblast growth factor （bFGF） in normal breast epithelia, benign breast disease and breast cancer and their relationship. Methods： Normal breast epithelia（ n = 10） , benign breast disease （ n = 45 ） and breast cancer （ n = 60） were ana- lyzed for Survivin, COX - 2 and bFGF expression by immunohistochemistry technique. Results ： Survivin was expressed in 73.33% in breast cancer. COX - 2 was expressed in 53.3% in breast cancer, bFGF was 41.7% in breast cancer. They were significantly different from the expression in benign breast disease （ P 〈 0.05 ）. Survivin, COX - 2 and bFGF expression were correlated with TNM stage, lymph mode metastasis （ P 〈 0.05 ）. Conclusion ： The expression of Survivin and COX -2 in breast cancer are higher than those in normal breast epithelia and benign breast disease . The expression of bFGF in breast cancer is higher than that in benign breast disease . Survivin COX -2 and bFGF probably play an important role in the tumorigenesis, development and metastasis of breast cancer. The effect of COX - 2 and bFGF are probably co - operation each other.

关 键 词：SURVIVIN COX-2 BFGF 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]