DEK蛋白在宫颈癌病因学中的意义研究  

Significance of DEK protein in pathogenesis of cervical cancer

作　　者：刘岿然[1] 赵敏[1] 张淑兰[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2011年第2期342-344,共3页Journal of Modern Oncology

基　　金：2008年辽宁省高等学校科研项目计划中华医学奖(编号:2008862);2009年中华医学科技奖叁等奖(编号:200903124P0860)

摘　　要：目的:检测DEK蛋白在正常宫颈、宫颈上皮内瘤变(CIN)及宫颈癌组织中的表达情况,探讨其在宫颈癌发病机制中的作用。方法:采用免疫组织化学方法检测DEK蛋白在35例宫颈癌组织,30例宫颈上皮内瘤变(CIN)及20例正常宫颈组织的表达情况,分析DEK蛋白的表达与宫颈癌发生的关系。结果:宫颈癌组织中DEK蛋白表达率(74.3%)高于宫颈上皮内瘤变组织(23.3%)和正常组织(15.0%),差异具有显著性意义(P<0.05),宫颈上皮内瘤变组织和正常组织,二者无统计学意义(P>0.05)。结论:DEK蛋白在宫颈癌中表达升高,可能与宫颈癌的发生有关,DEK蛋白可作为宫颈癌病因学的一个新指标。Objectlve：To detect DEK protein in cervical cancer, cervical intraepithelial neoplasia （CIN） and normal cervix and to explore the pathogenesis of cervical cancer. Methods： To detect DEK expression in 35 cases of cervical cancer , 30 cases of CIN and 20 cases of normal cervical tissue by immunohistoehemistry to inquire the relationship between DEK protein and the careinogenon of cervical cancer. Results ：The expression of DEK protein of cervical cancer tissue （ 74.3 % ） was higher than that of cervical intraepithelial neoplasia （23.3%） and normal tissue （15.0%） , the difference was significant （P 〈 0.05 ）. No significant difference between CIN and in normal tissue （P 〉 0.05 ） was observed. Conclusion： The expression of DEK protein in cervical cancer was increased which indicated the expression of DEK protein took part in the carcinogenesis of cervical cancer. It can be used as a new diagnostic indicators of cervical cancer.

关 键 词：DEK蛋白 免疫组织化学 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]