还原型谷胱甘肽防治化疗药物性肝损害效果观察  

Effect of tiopronin in the prevention and treatment of the hepatotoxicity caused by anti-tumor agents in cancer patients

作　　者：阿衣夏木古丽 陈锐[1] 

机构地区：[1]新疆维吾尔自治区人民医院肿瘤内科,新疆乌鲁木齐830001

出　　处：《现代肿瘤医学》2011年第2期352-354,共3页Journal of Modern Oncology

摘　　要：目的:观察双益健(还原型谷胱甘肽)对恶性肿瘤患者接受化疗时并发的化疗药物性肝损害的预防和治疗作用。方法:采用前瞻性对照研究,将148例患者分为2组,预防组74例在化疗同时予以还原型谷胱甘肽;对照组74例单纯化疗,该组患者如出现肝损害则使用还原型谷胱甘肽治疗(30例),观察比较两组患者在肝损害发生率及损害程度上的差异,并评价还原型谷胱甘肽治疗肝损害的疗效。结果:预防组比对照组在损害发生率低,有显著性差异(P<0.01);对照组中肝功能损害患者应用还原型谷胱甘肽治疗前后ALT,AST,FBIL及DBIL值变化有显著性差异(P<0.01)。结论:还原型谷胱甘肽预防和治疗恶性肿瘤患者化疗药物性肝损害治疗有效。Objective：To observe and evaluate the effects of reduced glutathione injection in the prevention and treatment of chemical hepatitis in patients with malignant tumor. Methods ： Total of 148 patients with malignant tumors were randomly divided into two groups. Prevention group （74 cases） received both anti -tumor agents and tiopronin during treatment. The control group （74 cases） only received anti - tumor agents. The patients of the control group who had chemical hepatitis received tiopro.nin treatment （30 cases）. Results：The rates of hepatotoxicity of the prevention group and control group were significantly different （ P 〈 0.01 ）. The patients of the control group who had chemical hepatitis received tiopronin treatment, and the levels of ALT, AST, TBIL and DBIL before and after treatment were significantly different （P 〈 0.01 ）. Conclusion：Reduced glutathione injection is effective in the prevention and treatment of the hepatotoxicity caused by chemotherapy in patients with malignant tumors.

关 键 词：还原型谷胱甘肽 化疗药物性肝损害 恶性肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]