环氧化酶-2基因多态性与肿瘤遗传易感性研究进展  

The study of COX-2 genetic polymorphisms and tumor hereditary susceptibility

作　　者：高婷花[1,2] 钱晓萍[2] 刘宝瑞[2] 

机构地区：[1]东南大学医学院,江苏南京210008 [2]南京大学医学院附属鼓楼医院肿瘤中心,江苏南京210008

出　　处：《现代肿瘤医学》2011年第2期364-367,共4页Journal of Modern Oncology

基　　金：江苏省南京市科技局国际联合研发项目(编号:201001138)

摘　　要：环氧化酶-2(cyclooxygenase-2,COX-2)是前列腺素(prostaglandins,PGs)合成过程中的关键限速酶之一,可将花生四烯酸代谢成各种PGs产物,从而维持机体的病理生理过程,参与炎症反应,疼痛反应,与肿瘤的发生、发展密切相关。因此,COX-2基因成为近年来研究的热点。最近国内外众多关于COX-2基因多态性与肿瘤易感性相关的病例对照研究,均表明COX-2单核苷酸多态性与多个肿瘤的易感性相关。这对肿瘤的个体化治疗有一定的指导作用。Cyclooxygenase -2 （COX -2） is one of the key rate -limiting enzymes in the conversion of arachidonic acid to prostaglandins （PGs） ,which participates in pathophysiological processes like inflammation,pain and also ap- pears to play a role in tumor occurrence and development. Thus, COX - 2 gene becomes the hot spot in current stud- ies. Recently, the most foreign and native case -control researches, with regard to the relation between COX -2 genetic polymorphisms and tumor susceptibility,clue to that there are some relationship between them. That may generate some guidance of individual treatment of cancer.

关 键 词：COX-2 基因多态性 遗传易感性 肿瘤 

分 类 号：R730.3[医药卫生—肿瘤]