4-甲基香豆素衍生物的合成研究  

Studies on the synthesis of 4methylcoumarin derivatives

作　　者：张铭龙[1,2] 王琳[1,2] 赵知中[1,2] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所 [2]北京医科大学天然仿生药物国家重点实验室

出　　处：《中国药学杂志》1999年第6期420-422,共3页Chinese Pharmaceutical Journal

摘　　要：目的：对天然具抗人类免疫缺陷病毒（ＨＩＶ）活性的香豆素ｃａｌａｎｏｌｉｄｅｓ，进行结构简化和改造，寻找具有抗艾滋病毒活性的香豆素。方法：以Ｐｅｃｈｍａｎｎ缩合法合成４甲基香豆素，并以它为母核进行结构修饰。结果：对７羟基（５，７二羟基）４甲基香豆素衍生物进行了合成。结论：完成了对ｃａｌａｎｏｌｉｄｅｓ的局部简化及结构改造。OBJECTIVE: To screen and modify calandides for their antiHIV activity. METHODS: 7hydroxy(5,7dihydroxy)4methyl coumarin derivatives were synthesized by Pechmann condensation reaction. RESULT: Some 4methyl coumarin derivatives were prepared.WT5HZCONCLUSION: The strucrute simplified calanolides derivatives were synthesized.In order to evaluate their activeties aganist HIV.

关 键 词：Pechmann反应 香豆素 艾滋病 合成 衍生物 

分 类 号：R914.5[医药卫生—药物化学] R512.91[医药卫生—药学]