视功能变异预见老年性黄斑变性的发生  

Abnormity of visualfunctionsmaypredictthedevelopmentofadvancedsenilemaculardegeneration

作　　者：陈松[1,2] 聂爱光[1,2] 姜德咏[1,2] 谭家铨 唐朝珍[1,2] 

机构地区：[1]湖南医科大学第二附属医院眼科 [2]天津市眼科医院

出　　处：《眼科研究》1999年第3期211-214,共4页Chinese Ophthalmic Research

摘　　要：目的探讨早期老年性黄斑变性（ＳＭＤ）视功能变异与ＳＭＤ发病的危险性，探讨ＳＭＤ早期诊断方法。方法对５４例（５４眼）早期ＳＭＤ患者进行了黄斑光敏度（ＭＬＳ）、ＦＭ１００色调试验、Ａｍｓｌｅｒ表、对比敏感度（ＣＳ）及暗适应检测。结果平均追踪５５月，追踪期内１８例患者发生了ＳＭＤ。回顾性分析显示ＳＭＤ组比玻璃疣组的视功能损害严重，中心凹、黄斑６°白色光敏度异常预见ＳＭＤ的发生的敏感性分别为８３．３７％及７７．７８％，特异性分别为８０．５５％及７５％。ＦＭ１００色调试验全色区预见发生ＳＭＤ的敏感性８３．３３％，特异性６３．６７％；Ａｍｓｌｅｒ表预见发生ＳＭＤ的敏感性７１．４０％，特异性８０％。结论采用ＭＬＳ、ＦＭ１００色调试验及Ａｍｓｌｅｒ表检测早期ＳＭＤ患者的视功能可较好地预见ＳＭＤ发生的危险性，为ＳＭＤ早期诊断提供敏感的检测方法。ObjectiveToinvestigatethe developmentofsenilemaculardegeneration(SMD),thevariationofvisualfunctionsinsuspectedSMDandmethodsofearlydiagnosisinSMD.MethodsVisualfunctiontestingwasperformedon54patients(54eyes)withsuspectedAMDbymacularlightsensitivity(MLS),FM100-Huetest,contrastsensitivity(CS),thresholdofdarkadaptationandAmslergrid in1989.Thesepatientswereallfollowedup(median55months).ResultsDuringthefollowupperiod,18patientsdevelopedadvancedSMD.RetrospectiveanalysisoftheresultsshowedthattheeyesthatdevelopedadvancedSMDsufferedmorecompromisedvisualfunctioncomparedtothosesubjectswithdrusen.Thedegreeoffovealoss,macularwhitelightsensitivity,huediscriminationandAmslergridin1989betterpredictedthosepatientsthatdevelopedadvancedSMDwith83.37%,77.78%,83.33%and71.40%sensitivity,respectivelyand80.55%,75.00%,63.67%and80.00%specificityrespectively.ConclusionMacularwhitelightandhuediscriminationsensitivityloss,andabnormalAmslergridtestwerebetterpredictorsofsubsequentdevelopmentofadvancedSMD.TheMLS,FM100huetestaarlydiagnosisofSMD.

关 键 词：黄斑变性 视功能 早期诊断 预后 老年人 

分 类 号：R774.5[医药卫生—眼科]