乳腺癌辅助化疗致闭经的研究进展  

Research advances on chemotherapy-induced aInenorrhea of breast cancer

作　　者：李永峰[1] 吴云飞[1] 

机构地区：[1]中国医科大学附属第一医院普通外科教研室乳腺外科,沈阳

出　　处：《国际肿瘤学杂志》2011年第2期132-135,共4页Journal of International Oncology

摘　　要：早期乳腺癌患者一般都有较好的预后,然而辅助化疗所导致的闭经却严重影响患者的生活质量和生育能力.年龄是化疗诱导停经的重要影响因素,而化疗方案对其并无显著影响.化疗致闭经（CIA）可改善激素受体阳性患者的无病生存率（DFS）和总生存率（OS）,对于低危或有生育要求的患者,应选用合适的方法保护患者的卵巢功能.The majority of women diagnosed with early-stage breast-cancer have an excellent long-term prognosis, but many still suffer from worsened life quality and infertility caused by chemotherapy-induced amenorrhea（CIA）. The risk of CIA varies by patient age, but is not significantly influenced by chemotherapeutic regimens. CIA will improve disease-free survival and overall survival for patients with hormonal receptor positive tumors. For low-risk patients and patients with the intention of maintaining fertility, proper treatments need to be chosen to preserve their reproductive function.

关 键 词：乳腺肿瘤 药物疗法 辅助 闭经 

分 类 号：R737.9[医药卫生—肿瘤]