查尔酮的结构修饰及抗癌、抗炎活性研究进展  

Research progress of the anti-cancer,anti-inflammatory activities of chalcone as bioactive plant constituents

作　　者：李湘洲[1] 郭远良[1] 旷春桃[1] 贺义昌[1] 

机构地区：[1]中南林业科技大学材料科学与工程学院,湖南长沙410004

出　　处：《中南林业科技大学学报》2011年第2期95-99,共5页Journal of Central South University of Forestry & Technology

基　　金：国家科技部"十一五"科技支撑计划重点项目(2006BAD18B0404);教育部博士点基金(20094321110001);湖南省教育厅重点项目(08A084);湖南省科技计划项目(2007NK3119);长沙市科技局重点项目(K0802109-21)

摘　　要：查尔酮类化合物是广泛存在于自然界中一种黄酮类化合物,具有抗癌、抗炎症、抗菌、抗寄生虫、抗病毒等生物活性,是一类很具有前途的药物模板。重点阐述了近年来查尔酮类化合物的抗癌、抗炎症活性以及构效关系研究进展。结果表明查尔酮类化合物药理活性广泛、安全、结构简单且制备方便,是一个良好的药物开发先导物。Chalcone, which are abundant in plants as a class of flavonoids, are confirmed to possess a diverse array of pharmacological activities and considered as a promising template for drug design. The studying progress on anticancer, anti inflammatory activities of chalcone, and the structure-activity relationship（SAR）was summarized. The findings indicate that chalcone has widely pharmacology activity, safety, simple structure, preparation convenient, and is a kind of good primer for drug development.

关 键 词：查尔酮 抗癌 抗炎症 构效关系 

分 类 号：S632.5[农业科学—蔬菜学] TS201[农业科学—园艺学]