腹针“补肾填髓”法静息状态脑功能成像研究  

Study on response of resting-state functional magnetic resonance imaging induced by abdominal acupuncture with invigorating the kidney and nourishing marrow method

作　　者：钟治平[1] 吴珊珊[1] 陈志光[1] 刘波[1] 

机构地区：[1]广东省中医院影像科,广州510120

出　　处：《中国针灸》2011年第2期139-143,共5页Chinese Acupuncture & Moxibustion

摘　　要：目的:利用静息状态脑功能磁共振成像研究腹针的中枢神经作用机制。方法:对12例老年健康志愿者进行标准化腹针"补肾填髓"法操作,穴取中脘、下脘、气海、关元、气穴、商曲、滑肉门,于针刺前和针刺起针后行磁共振静息状态脑功能成像扫描,采用双侧海马为种子点对全脑皮层进行功能连接分析。结果:①针刺前,双侧额中回、双侧颞上回、双侧颞中回、双侧丘脑、双侧海马旁回、双侧岛叶、右侧小脑顶、右侧小脑坡、左侧额上回、左侧尾状核头、左侧后扣带回、左侧顶下小叶与双侧海马存在功能连接(均P<0.05)。②针刺后,双侧额上回、双侧颞上回、双侧颞中回、双侧丘脑、双侧岛叶、双侧海马旁回、双侧顶下小叶、双侧中央后回、双侧扣带回、右侧尾状核头、右侧枕中回、右侧后扣带回与双侧海马存在功能连接(均P<0.05)。③针刺后与针刺前比较,双侧额上回、双侧额中回、双侧颞上回、双侧顶上小叶、右侧额下回、右侧前扣带回、右侧梭状回、右侧楔前叶、右中央后回与双侧海马的功能连接增强;左侧颞中回、右侧舌回、左侧楔叶、左侧楔前叶、左侧顶下小叶与双侧海马的功能连接减弱。结论:老年健康志愿者腹针"补肾填髓法"针刺后与认知、记忆及情感、感觉有关的皮层结构与双侧海马的功能连接增强,提示腹针可改善中枢神经系统认知网络的整体功能状态。Objective To approach the central nervous mechanism of abdominal acupuncture by using resting state functional magnetic resonance imaging （fMRI）. Methods Twelve old healthy volunteers were treated by standardized abdominal acupuncture with invigorating the kidney and nourishing marrow method and Zhongwan （CV 12）, Xiawan （CV 10）, Qihai （CV 6）, Guanyuan （CV 4）, Qixue （KI 13）, Shangqu （KI 17） and Huaroumen （ST 24） were selected. They were examined by using resting-state fMRI before and after treatment of abdominal acupuncture and the brain functional connectivities were analyzed based on bilateral hippocampus chosen as seed points. Results （1） Before acupuncture, functional connectivities were found in the bilateral middle frontal gyrus, bilateral superior temporal gyrus, bilateral middle temporal gyrus, bilateral thalamus, bilateral subiculum hippocampi, bilateral insula, the cupula and declivis of right cerebellum, left superior frontal gyrus, left head of caudate nucleus, left posterior cingulate gyrus and left inferior parietal lobule （all P〈0.05）. （2） After acupuncture, functional connectivities were found in the bilateral superior frontal gyrus, bilateral superior temporal gyrus, bilateral middle temporal gyrus, bilateral thalamus, bilateral insula, bilateral subiculum hippocampi, bilateral inferior parietal lo bule, bilateral postcentral gyrus, bilateral cingulate gyrus, right head of caudate nucleus, right middle occipital gyrus and right posterior cingulate gyrus （all P〈0.05）. （3）After acupuncture, there were intensity functional connectivities greater than before acupuncture in the bilateral superior frontal gyrus, bilateral middle frontal gyrus, bilateral superior temporal gyrus, bilateral superior parietal lobule, right inferior frontal gyrus, right anterior cingulate gyrus, right fusiform gyrus, right precuneus and right postcentral gyrus, while the intensity of functional connecti vities of left middle temporal gyrus, right lingual gyrus,left cune

关 键 词：针刺疗法 脑 磁共振光谱法 腹针 

分 类 号：R224[医药卫生—中医基础理论]