荜澄茄超临界二氧化碳萃取提取物的药效学研究  

Pharmacodynamic Study on Supercritical CO_2 Extract from Fructus Litseae

作　　者：汤杰[1] 万进[1] 施春阳[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《医药导报》2011年第2期193-196,共4页Herald of Medicine

摘　　要：目的以超临界二氧化碳(SC-CO2)技术萃取荜澄茄挥发性成分,并观察其药效。方法以管碟法考察荜澄茄超临界二氧化碳萃取提取物体外抑菌活性,采用醋酸致腹腔毛细血管通透性增加及二甲苯致耳廓肿胀试验观察其抗炎活性,并观察其对化学及物理刺激所致疼痛的抑制作用。结果荜澄茄SC-CO2提取物体外对金黄色葡萄球菌、铜绿假单胞菌有一定的抑菌活性,能够抑制醋酸所致小鼠腹腔毛细血管通透性增加。Objective To extract the volatile components from Fructus Litseae with a supercritical CO2 extraction technique and observe its pharmacodynamic activity. Methods The sensitivity of extracts from Fructus Litseae against Staphylococcus aureus and Pseudomonas aeruginosa was determined with an agar diffusion method.Its anti-inflammation effect was studied by measuring capillary permeability induced by intraperitoneal injection with acetic acid,swelling of the pinna in mice induced by xylene.Its analgesia effect was investigated in the murine pain models induced by chemical and physical stimulations. Results The bacteriostasis activity of the supercritical CO2 extracts from Fructus Litseae in vitro was confirmed.The extracts significantly inhibited two experimental animal inflammatory models and alleviated pain induced by acetic acid and fever. Conclusion It is preferable and reasonable to extract volatile components from Fructus Litseae,the extract of which is shown to have remarkable activity.

关 键 词：荜澄茄 超临界二氧化碳萃取 抑菌 抗炎 镇痛 

分 类 号：R285.5[医药卫生—中药学] R965[医药卫生—中医学]