碱性成纤维细胞生长因子在正常和炎性牙髓中的免疫组化研究  

Immunolocalization of Basic Fibroblast Growth Factor(bFGF) in Healthy and Inflamed Dental Pulp.

作　　者：徐劲军[1] 雷芳[1] 何红英[1] 

机构地区：[1]湖北医科大学口腔医学院

出　　处：《广东牙病防治》1999年第3期170-171,共2页Journal of Dental Prevention and Treatment

摘　　要：目的研究牙髓组织标本中碱性成纤维细胞生长因子（ｂＦＧＦ）的表达和分布。方法用免疫组化方法研究。结果成纤维细胞、内皮细胞以及细胞外基质成分的ｂＦＧＦ呈阳性反应。正常组ｂＦＧＦ的成纤维细胞数目显著高于慢性牙髓炎组（Ｐ＜０．０５）。结论在牙髓组织中，ｂＦＧＦ主在在成纤维细胞和内皮细胞上表达，炎性牙髓组织中ｂＦＧＦ的表达水平下调可能与炎症的损伤和修复有关。Objective To examine the distribution of basic fibroblast growth factor (bFGF) in human dental pulpal tissue with SABC. Method Immunohistochemical stain. Results Fibroblast, endothelial cell and extrcellular matrix (ECM) stained positively for bFGF. Histological cell counts revealed that the number of positive fibroblasts was greater in health group than in chronic pulpitis group ( P <0.05). Conclusion bFGF is produced primarily by fibroblasts and endothelial cells in dental pulpal tisstue. That bFGF levels decreased in inflamed tissue may be related to inflammation injury or tissure restoration.

关 键 词：碱性成纤维细胞 生长因子 牙髓炎 免疫组化 

分 类 号：R781.310.2[医药卫生—口腔医学]