长期应用小剂量阿司匹林联合尼达尔对短暂性脑缺血发作脑血流的影响  

Influence of longterm application of small dose aspirin with nimodipine on the transient cerebral ischemia

作　　者：梁军涛[1] 王剑伟[1] 刘平 赵彤[1] 

机构地区：[1]秦皇岛市北戴河医院

出　　处：《中国疗养医学》2011年第2期164-165,共2页Chinese Journal of Convalescent Medicine

摘　　要：目的观察长期应用小剂量阿司匹林联合尼达尔对短暂性脑缺血发作(TIA)患者脑血流的影响。方法治疗组54例患者均口服肠溶阿司匹林片50mg、尼达尔20mg,1次/d,晚餐后或睡前顿服,连续服用1年;对照组48例患者均口服肠溶阿司匹林片50mg,1次/d,晚餐后或睡前顿服,连续服用1年。两组患者接受治疗前及治疗后6个月、1年均各检查一次经颅多普勒(TCD)。结果 TCD结果统计显示治疗组与对照组患者脑血流改善有明显差别,差异有统计学意义(P<0.05)。结论长期应用小剂量阿司匹林联合尼达尔可以明显改善TIA患者的脑血流供应,能减少再发作及减低脑梗死发生的机会,作为TIA预后干预性治疗的方法,值得推广。Objective To observe influence of long-term application of low-dose aspirin and Nidal on cerebral blood flow of patients with transient ischemic attacking（TIA）.Methods After dinner or before sleep,54 cases of patients in the treatment group orally administrated 50 mg enteric-coated aspirin tablets and 20 mg Nidal once a day for one year.After dinner or before sleep,48 cases of patients in the control group orally administrated 50 mg enteric-coated aspirin tablets once a day for one year.For patients in the two groups,transcranial Doppler（TCD）tests were respectively carried out once before treatment and at 6 months and one year after treatment.Results TCD results showed that there was significant difference for cerebral blood flow of patients between the treatment group and the control group（P〈0.05）.Conclusion long-term application of low-dose aspirin and Nidal could significantly improve cerebral blood flow supply of TIA patients and could reduce chance of the occurrence and cerebral infarction incidence.As one method of intervention treatment of TIA prognosis,it was desirable to be popularized.

关 键 词：TIA TCD 阿司匹林 尼达尔 

分 类 号：R743.3[医药卫生—神经病学与精神病学]