胃癌组织cyclin E表达的临床病理意义  

Cyclin E expression in gastric carcinoma and its clinicopathological significance

作　　者：刘晓波[1] 李里 庄宝珠[2] 姜彦多[3] 王继红[3] 

机构地区：[1]中国人民解放军沈阳202医院消化内科,辽宁省沈阳市110003 [2]中国医科大学附属一院消化内科,辽宁省沈阳市110001 [3]中国人民解放军沈阳202医院病理科,辽宁省沈阳市110003

出　　处：《世界华人消化杂志》1999年第8期656-658,共3页World Chinese Journal of Digestology

摘　　要：目的　Ｃｙｃｌｉｎ Ｅ 蛋白在细胞周期的Ｇ１ 晚期起作用，加速Ｇ１Ｓ期转化，与人类肿瘤有关． 本研究探讨ｃｙｃｌｉｎ Ｅ 蛋白在胃癌的意义．方法　用敏感而特异的免疫组化ＳＰ 法测定胃癌石蜡切片中ｃｙｃｌｉｎ Ｅ蛋白的异常表达．结果　Ｃｙｃｌｉｎ Ｅ 在胃癌中表达６２ ％ （ｎ ＝ ６０ ，Ｍ＝ ４３ ，Ｆ＝ １７ ，３２岁～７３ 岁） ，与癌旁组织２６ ％ 相比有显著差异（ Ｐ＜ ０－０５） ．Ｃｙｃｌｉｎ Ｅ表达与组织病理分化程度呈负相关． 分化差的胃癌组织ｃｙｃｌｉｎ Ｅ蛋白表达越强，ｃｙｃｌｉｎ Ｅ与肿瘤侵袭、淋巴结转移、远处转移无明显关系．结论　Ｃｙｃｌｉｎ Ｅ 蛋白与胃癌发生有关，与胃癌进展无关．ＣｙｃｌｉｎＥ 蛋白可做为胃癌的一个潜在的诊断和判断预后的指标．AIM Cyclin E protein acts in late G 1 of cell cycle and accelerates the G 1 to S transition, cyclin E is associated with the human cancer. The aim of this study was to investigate the significance of the cyclin E protein expression in gastric carcinoma. METHODS Cyclin E protein overexpression was studied in paraffin embedded sections of gastric carcinoma by means of a specific and sensitive immunohistochemical SP assay. RESULTS Cyclin E protein expression was present in 62% (37/?60) gastric carcinoma, which showed a significant difference from those of normal tissues adjacent to tumors (26%) ( P <0 05). Cyclin E expression was negatively correlated with histological differentiation. Gastric carcinoma with poor differentiation showed increased cyclin E expression, cyclin E was not related to the invasion of tumor, lymph node and distant metastasis. CONCLUSION Cyclin E is involved in the genesis of gastric carcinoma and not contributes to its development. Cyclin E protein is a potential diagnostic and prognostic marker for gastric cancer.

关 键 词：细胞周期蛋白 胃肿瘤/病理学 免疫组织化学 基因表达 

分 类 号：R735.202[医药卫生—肿瘤]