丁螺环酮联合米氮平治疗老年期抑郁症的对照研究  

Effect of combination treatment of buspirone hydrochloride and mirtazapine on elderly patients with depression

作　　者：尹定富 曹秀英[1] 冯锦[1] 王超群[1] 

机构地区：[1]黄石市精神病医院老年科,湖北省黄石市435004

出　　处：《实用老年医学》2011年第1期56-57,61,共3页Practical Geriatrics

摘　　要：目的观察丁螺环酮联合米氮平治疗老年期抑郁症的疗效和安全性。方法 57例老年抑郁症患者分为2组,丁螺环酮联合米氮平治疗30例,为研究组,单用米氮平27例,为对照组。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和不良反应量表(TESS)分别观察疗效和不良反应,连续观察6周。结果在治疗第1周,2组HAMD和HAMA评分均下降,但2组间有显著性差异(P<0.01)。第2周末开始2组间HAMD和HAMA评分差异无显著性。第6周末2组显效率分别为83.3%和81.5%,差异无统计学意义(P>0.05)。2组间TESS评分每周差异亦无统计学意义(P>0.05)。结论丁螺环酮联合米氮平治疗老年期抑郁症起效更快,病人的满意度和依从性更好。Objective To observe the effect of combination treatment of buspirone hydrochloride and mirtazapine on depression in the elderly and to assess the safety. Methods Fifty-seven elderly patients with depression were divided in- to two groups ： study group treated with combination of buspirone hydrochloride and mirtazapine with thirty patients and con- trol group treated only with mirtazapine with twenty-seven patients. Hamilton Depression Rating Scale（HAMD）, Hamilton Anxiety Scale（HAMA） and Side Effects Scale（TESS） were used for six weeks to observe the effectiveness and adverse re- actions. Results At the first treatment weekend, HAMD and HAMA scores were decreased in both groups and there were significant differences between the two groups （P 〈 0. 01 ）. After the second weekend, there were no significant differences between the two groups in HAMD and HAMA scores. At the sixth weekend, the effective rate of the two groups were 83. 3% and 81.5% respectively, without statistical differences. And there were no remarkable differences between the two groups in TESS scores at each weekend. Conclusions Compared with mirtazapine, combination of buspirone hydrochlo- ride and mirtazapine in the treatment for depression in the elderly has faster and greater effectiveness with more patients＇ satisfaction and better compliance.

关 键 词：丁螺环酮 米氮平 老年人 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]