早年创伤经历与强迫症的相关性研究  

Association study between early trauma experience and obsessive-compulsive disorder

作　　者：王雪梅[1] 王振[1] 徐海婷 肖泽萍[1] 

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030

出　　处：《中华行为医学与脑科学杂志》2011年第1期7-9,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家“863”计划高技术研究发展计划（2007AA022420）;国家自然科学基金（30800370）;上海市市级医院新兴前沿技术项目（SHDC12006105）;上海交通大学医学院“博士创新基金项目”（BXJ201047）;上海市优秀学科带头人计划（08XD14036）

摘　　要：目的探讨早年创伤经历与强迫症的相关性，并进一步探讨其与强迫症的起病年龄、病程及严重程度的相关性。方法对符合DSM-Ⅳ诊断标准的185例强迫症患者以及132例健康对照进行早年创伤问卷简表（ETI—SF）评估，并对强迫症患者进行临床资料及Yale—Brown强迫量表的评定。结果相对于对照组，强迫症组早年创伤量表总分更高[（3．55±3．29）分，（1．51±1．98）分，P〈0．01]，而且4个维度得分也均高于对照组，其中普通创伤[（0．89±1．10）分，（0．43±0．77）分，P〈0．01]，躯体创伤[（0．98±1．31）分，（0．65±1．04）分，P=0．016]，情感虐待[（1．43±1．61）分，（0．38±0．89）分，P〈0．01]，性创伤[（0．24±0．59）分，（0．06±0．30）分，P〈0．01]，且女性强迫症患者性创伤多于男性患者[（0．33±0．69）分，（0．16±0．45）分，P=0．049]。早年创伤总分及各维度分值（除外性创伤）与强迫症患者的起病年龄成负相关（P〈0．01）。结论强迫症患者有较多的早年创伤经历，且经历越多，其起病年龄越早，早年创伤经历可能是强迫症发生发展的重要环境因素之一。Objective To investigate the association between early trauma experiences and obsessivecompulsive disorder （OCD）. Methods One hundred and eighty-five patients who met with OCD diagnosis of DSM-IV and one hundred and thirty-two healthy controls were recruited. Early trauma experience of all participants was assessed with Early Trauma Inventory-Short Form （ETI-SF） ,and severity of symptoms of OCD patients was evaluated with Yale-Brown Obsessive-Compulsive Severity Scale （ Y-BOCS ）. Results When compared with controls,OCD group showed significantly higher in ETI-SF total score （3.55 ± 3.29 vs 1.51±1.98, P〈0. 01 ） and had greater in general trauma （0.89 ±1.10 vs 0.43 ± 0.77, P 〈 0.01 ） ,physical abuse （0.98 ± 1.31 vs 0.65 ± 1.04, P = 0.016 ）, emotional abuse （ 1.43 ±1.61 vs 0.38± 0.89, P 〈 0.01 ） , and sexual abuse （ 0.24 ±0.59 vs 0. 06±0. 30 , P〈0. 01 ）. Female OCD patients reported more sexual abuse than male patients（0.33 ±0.69 vs 0.16±0.45, P = 0.049） . There was a negative a nelation between onset age of obsessive symptoms and early trauma experiences（P 〈 0.01 ） , except sexual abuse experiences （P = 0. 10）. Conclusion OCD patients have much more childhood traumas, and the more trauma experiences are, the earlier onset of OCD is,which may associated with the development of obsessive-compulsive disorder.

关 键 词：强迫症 早年创伤 耶鲁-布朗强迫量表 早年创伤问卷简表 

分 类 号：R749.7[医药卫生—神经病学与精神病学]