SARS冠状病毒S蛋白的研究进展  

Recent Advance in the Research of SARS Coronavirus Spike Protein

作　　者：蔡锦源[1] 江晓燊[2] 王志祥[1] 顾觉奋[1] 

机构地区：[1]中国药科大学,南京210009 [2]广西医科大学,南宁530021

出　　处：《国外医药（抗生素分册）》2011年第1期1-5,共5页World Notes on Antibiotics

摘　　要：SARS冠状病毒S蛋白是典型的I型病毒融合蛋白,在很大程度上决定了SARS冠状病毒的组织嗜性和致病性。近年来,SARS冠状病毒S蛋白已经成为研究的热点。本文就SARS冠状病毒及其S蛋白的分子生物学特点、SARS冠状病毒入境关系、在膜融合过程作用、基因研究、与血管紧张素转化酶2(ACE2)的相互作用、受体结合域、SARS疫苗研究中的作用等综述了近年来SARS冠状病毒S蛋白的研究进展。SARS-Cov protein S was a typical type I virus fusion protein, to a large extent determines the SARS coronavirus in the tissue tropism and pathogenicity. In recent years, SARS-CoV S protein had become a research focus. In this paper, Recent advance in the research of SARS coronavirus S protein had been reviewed, including the biology molecular of SARS-Cov with protein S, the entry relationship of SARS-CoV, role in the process of membrane fusion, gene research, and angiotensin-converting enzyme 2 （ACE2） interactions, receptor binding domain, and the role of vaccine research of SARS.

关 键 词：SARS冠状病毒 S蛋白 膜融合 SARS疫苗 

分 类 号：Q816[生物学—生物工程]