STAT3与WWOX在非小细胞肺癌中的表达及意义  

CLINICAL SIGNIFICANCE AND EXPRESSION OF STAT3 AND WWOX IN HUMAN NON SMALL CELL LUNG CANCER

作　　者：胡福英 王乐朋[2] 侯莉莉[3] 王鸿程[2] 殷刚[4] 

机构地区：[1]湖北省天门市一医院呼吸内科,湖北天门431700 [2]泸州医学院附属医院呼吸内科 [3]河北省胸科医院呼吸内科 [4]湖北天门市第一人民医院普外科

出　　处：《泸州医学院学报》2011年第1期16-19,共4页Journal of Luzhou Medical College

基　　金：四川省科技厅重点基金项目(2006j13-192)

摘　　要：目的:研究STAT3与WWOX在非小细胞肺癌及肺正常组织中的表达及两者之间的关系。方法:应用免疫组织化学S-P法,检测STAT3、WWOX在40例非小细胞肺癌组织、20例正常肺组织中的表达情况,并分析其与各临床病理指标之间的关系。结果:①STAT3在非小细胞肺癌组织中的表达明显高于肺正常组织(P<0.01),WWOX在非小细胞肺癌组织中的表达明显低于肺正常组织(P<0.01)。②STAT3在腺癌组织中的表达明显高于鳞癌(P<0.01),WWOX基因的表达与淋巴结转移相关(P<0.01),在有淋巴结转移的肺癌组织,其表达更少或缺失。③STAT3蛋白与WWOX在非小细胞肺癌中的表达呈负相关(P<0.01)。结论:①非小细胞肺癌中有组成性激活的STAT3信号通路,提示STAT3信号通路在非小细胞肺癌发生、发展中发挥重要作用;②STAT3与WWOX在非小细胞肺癌中的表达呈负相关。Objective：To investigate the expression of STAT3 and WWOX in non-small cell lung cancer（NSCLC） and their clinical significance,and study their relation ship.Methods：Forty resected tissue samples from patients with NSCLC and twenty normal lung tissues were subjected to immunohistochemical staining（SP） for STAT3 and WWOX.Results：①The positive expression rate of STAT3 was apparently higher than normal lung tissues（P〈0.01）;the positive expression rate of WWOX was apparently lower than normal lung tissues（P〈0.01）.②The expression level of STAT3 was related to pathologic types in NSCLC,which in adenocarcinomas were higher than in squmous cell carcinomas（P〈0.01）.The expression of WWOX was ralated to lymph node metastasis in NSCLC（P〈0.01）.③There was a negative correlation between the expressions of STAT3 and WWOX（P〈0.01）.Conclusions：①The fndings demonstrate that STAT3 signaling transduction pathway is constitutively activated in non-small lung cancer cell suggesting that STAT3 may plays a critical role in the genesis and development of non-small cell lung cancer.②There was a negativie correlation between the expressions of STAT3 and WWOX.

关 键 词：信号转导与转录激活因子3 包含氧化还原酶的WW域 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]