文拉法辛缓释片与米安合林治疗老年抑郁症对照研究  

A controlled study of venlafaxine extended release tablets vs. mianserin in the treatment of senile depression

作　　者：贡永宁[1] 郭平[1] 

机构地区：[1]驻马店市精神病医院,河南驻马店463000

出　　处：《临床心身疾病杂志》2011年第1期21-22,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨文拉法辛缓释片与米安舍林治疗老年抑郁症的临床疗效及安全性。方法将78例老年抑郁症患者随机分为两组，每组38例，研究组晨口服文拉法辛缓释片治疗，对照组每晚口服米安舍林治疗，观察8周。于治疗前及治疗2周、4周、6周、8周末采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果研究组治疗2周末起，对照组治疗4周末起，汉密顿抑郁量表总分均较治疗前有显著下降（P〈0．01）；但研究组治疗2周末较对照组下降更显著（P〈0．05），其他时段评分均无显著性差异（P〉0．05）；副反应量表各时段评分研究组均显著低于对照组（P〈0．05）；治疗8周末两组总有效率均为89．47％。结论文拉法辛缓释片治疗老年抑郁症疗效显著，且与米安舍林疗效相当，但文拉法辛缓释片较起效更快，安全性更高，依从性更好。Objective To explore clinical efficacy and safety of venlafaxine extended release tablets vs. mianserin in the treatment of senile depression. Methods Seventy-eight senile patients with depression were randomly assigned to two groups of 38 ones each, research group took orally venlafaxine extended release tablets q.m. and control group did mianserin q.n. for 8 weeks. Clinical efficacies were assessed with the Hanmilton Depression Scale （HAMD） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before treatment and at the end of the 2nd, 4th, 6th and 8th week. Results The total scores of the HAMD lowered more significantly since the end of the 2na week in the research and in the control group since the 4th compared with pretreatment （P〈0.01） ; at the end of the 2^nd week, those did more signifi- cantly in the research than in the control group （P〈0.05）, there were no significant differences in other points （P〉0.05） ; all points scores of the TESS were significantly lower in the research than in the control group （P〈0.05） ; at the end of the 8th week, total effective rates of both groups were 89.47%. Conclusion Venlafaxine extended release tablets have an evident effect equivalent to mianserin in the treatment of senile depression, but the former take effect more rapidly, have higher safety and better compliance.

关 键 词：老年抑郁症 文拉法辛缓释片 米安舍林 汉密顿抑郁量表 副反应量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]