阿奇霉素固废处置及对甲苯磺酰氯的回收与精制  

Recovery of P-Toluenesulfonyl Chloride from Dregs Generated in Azithromycin Production

作　　者：邓鹏飞[1] 刘颖 史载锋[1] 吴虎成 罗由萍[1] 赵凯[1] 

机构地区：[1]海南师范大学化学与化工学院海南省热带药用植物化学重点实验室,海南海口571158 [2]浙江海翔药业股份有限公司,浙江台州318000 [3]海口菁英环宇医药科技有限公司,海南海口571100

出　　处：《广东化工》2011年第2期30-31,50,共3页Guangdong Chemical Industry

摘　　要：研究了从阿奇霉素生产废渣中回收对甲苯磺酰氯的方法,探讨了重结晶溶剂种类、碱洗液种类和浓度以及吸附剂对回收效果的影响。结果表明,用10%氢氧化钠碱洗,活性炭脱色,石油醚重结晶,活性炭和硅胶(质量比为9∶1)吸附不溶性杂质,冷却析晶,乙酸乙酯和石油醚循环套用,得到白色对甲苯磺酰氯,纯度通过高效液相色谱检测达到99%。The method for extracting p-toluenesulfonyl chloride from dregs generated in azithromycin production was studied. The effects of solvent, alkali and absorbent were discussed. The results indicate that the 10 % sodium hydroxide solution to neutralize the free acid, absorb with active carbon, recrystallization with petroleum ether, the yield of p-toluenesulfonyl Chloride was 65.5 %. The purity of TsCl was as high as 99 % according to the determination by HPLC.

关 键 词：阿奇霉素 制药 固废 对甲苯磺酰氯 综合利用 

分 类 号：TQ247.52[化学工程—有机化工]