HnRNP A2/B1及p21WAF1蛋白在非小细胞肺癌中表达及意义  

Expression of HnRNP A2/B1 and p21WAF1 proteins in human non-small cell lung carcinoma tissue

作　　者：韩军[1] 向靖[1] 陆友金[1] 

机构地区：[1]安徽医科大学第二附属医院呼吸内科,安徽合肥230601

出　　处：《临床肺科杂志》2011年第3期391-393,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨核内不均一核糖核蛋白A2/B1(hnRNP A2/B1)和p21WAF1蛋白在人非小细胞肺癌(NSCLC)组织中的表达,并进行相关性分析。方法采用免疫组化S-P法检测53例NSCLC组织、40例癌旁组织、7例肺良性病变组织中hnRNPA2/B1和p21WAF1表达。结果 NSCLC组织中hnRNP A2/B1和p21WAF12种蛋白的阳性表达率分别为66.0%和45.2%,显著高于癌旁肺组织和肺良性病变肺组织,差异有统计学意义(P<0.05)。它们均与分化程度、淋巴结转移有关(P<0.05),与组织类型、临床分期无关(P>0.05)。两种蛋白在NSCLC表达呈显著负相关(P=0.001)。结论 hnRNP A2/B1可能通过下调p21WAF1的表达而缩短细胞周期,促进NSCLC的癌细胞增殖。Objective To investigate the expression of HnRNP A2/B1 and p21WAF1 proteins in Non-small cell lung carcinoma（NSCLC）tissues and analyze the correlation between them.Methods The expression of HnRNP A2/B1 and p21WAF1 were detected by inmmunohis-tochemistry S-P method in 53 cases of NSCLC,40 paracanceious tissues and 7 benigh pulmonary lesions tissues.Results In NSCLC,hnRNP A2/B1 and p21WAF1proteins postive expression rates were 66.0%（35/53）and 45.2%（24/53）respectively,significantly higher than those in paracanceious tissues and benigh pulmonary lesions tissues（P0.05）.The postive expression rate of HnRNP A2/B1 and p21WAF1in NSCLC were associated with differentiation degree and lymph node metastasis（P0.05）,except for histological types and clinical stage（P0.05）.In NSCLC,a negative correlation were present between HnRNP A2/B1 and p21WAF1 protein expression（P=0.001）.Conclusion By upregulated the expression of p21WAF1,HnRNP A2/B1 reduced cell cycle and promoted the proliferation of cancerous cell of NSCLC.

关 键 词：癌 非小细胞肺 HnRNPA2/B1 p21WAF1 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]