精神分裂症患者迟发性运动障碍与糖代谢异常关系探讨  

Relationship between glycometabolism and tardive dyskinesia in schizophrenia patients

作　　者：张喜梅[1] 朱凤艳[2] 尚兰[1] 谭云龙[3] 石夏明[2] 魏立和[1] 张建新[1] 杨甫德[3] 邹义壮[3] 

机构地区：[1]北京回龙观医院四科,100096 [2]北京回龙观医院三科,100096 [3]北京回龙观医院精神医学研究中心,100096

出　　处：《中华精神科杂志》2011年第1期36-38,共3页Chinese Journal of Psychiatry

摘　　要：目的 探讨迟发性运动障碍（TD）与糖代谢之间可能存在的关系.方法 采用Simpson迟发性运动障碍专用量表筛选出符合入组标准的TD患者（TD组）30例和非TD患者（非TD组）32例,采用阳性与阴性症状评定量表（PANSS）评定精神病理症状的严重程度,采用异常不自主运动量表（AIMS）评定TD症状的严重程度,采用全自动生化仪测定同一时间患者空腹血糖、血清胰岛素、胰岛素抵抗指数、糖化血红蛋白,比较2组患者糖代谢指标的差异,并分析TD患者糖代谢指标水平与AIMS总分间的关系.结果 TD组空腹血糖[（5.74±1.36）mmol/L]高于非TD组[（5.05±0.91）mmol/L],差异有统计学意义（F=6.619,P=0.013）;TD组患者AIMS评分与血清胰岛素（r=0.469）、空腹血糖（r=0.512）及胰岛素抵抗指数（r=0.483）呈正相关（P均＜0.05）.结论 TD组较非TD组糖代谢异常明显,糖代谢异常可能与TD的发生有一定关系.Objective To explore the relationship between glycometabolism and tardive dyskinesia in schizophrenia patients. Methods Thirty schizophrenia patients with TD and 32 without TD were recruited by using the Simpson dyskinesia scale. They were assessed with the Positive and Negative Symptom Scale （ PANSS ） and Abnormal Involuntary Movement Scale （ AIMS ） （ Chinese version ）. The levels of FINS （ fasting insulin ）, IRI（ insulin resistance index ）, GHB（ glycolated hemoglobin ）and FPG（ fasting plasma glucose ）were measured. The relationship between glycometabolism and TD was analysed. Results The levels of FPG were significantly higher in schizophrenia patients with TD [（ 5.74 ± 1.36 ）mmol/L] than the patients without TD[（ 5.05 ± 0. 91 ）mmol/L] （ F = 6. 619, P = 0. 013 ）. The AIMS scores were positively correlated with levels of FINS（ r = 0. 469, P 〈 0. 05 ）, FPG（ r = 0. 512, P 〈 0. 05 ）and IRI（ r = 0. 483, P 〈0. 05 ）. Conclusions Glycometabolism may be involved in the pathophysiological process of TD.

关 键 词：运动障碍 药物性 精神分裂症 胰岛素 血糖 胰岛素抗药性 血红 蛋白类 

分 类 号：R749.3[医药卫生—神经病学与精神病学]