动物行为学在中药寒热药性研究中的思考与实践  

Thinking and practice of animal ethology in study of Cold and Hot nature of traditional Chinese medicine

作　　者：邢小燕[1,2] 赵艳玲[1] 孔维军[1,2] 贾雷[1,2] 王伽伯[1] 鄢丹[1] 李瑞生[3] 肖小河[1] 

机构地区：[1]解放军第302医院解放军中药研究所,北京100039 [2]成都中医药大学,四川成都610075 [3]解放军第302医院动物实验中心,北京100039

出　　处：《中国中药杂志》2011年第4期519-524,共6页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(973)项目(2007CB512607;2006CB504703)

摘　　要：从宏观动物行为学角度,结合计算机和现代影像处理技术,通过监测动物在具有不同寒热属性药物的作用下对环境温度趋向性行为的变化,获得通过直接观察难以评定的多行为学参数,评价药物的寒热属性,进而表征其寒热属性的差异。该方法可实时在线、无扰、直观且客观、定性且定量地监测实验动物的寒热趋向性,从整体动物水平表征中药寒热药性,符合中药用药特点,适应于中医药理论体系,是中药药性研究方法的一次大胆尝试,为探讨中药寒热药性与动物对温度趋向行为变化的内在联系,阐明中药寒热药性的客观真实性与科学内涵,建立符合中药应用特点的寒热药性客观评价方法,审视和研究中药药性乃至整个中医药基础理论提供了新的视角和技术平台。From the view of macroscopic animal ethology combined with computer and modern image processing technique, by monitoring the temperature tropism of animal affected by traditional Chinese medicine （TCM） with different Cold and Hot natures and obtaining many behavior parameters which were difficult to assess in direct observation, the differences between the Cold and Hot nature of TCM were evaluated and presented. This method could real-time, intuitively and objectively, qualitatively and quantitatively monitor the temperature tropism of experimental animals with no disturbance. Further, the Cold and Hot nature of TCM can be expressed from the whole animal level. This method met to the application peculiarity of TCM and suited for the TCM theoretical system. It is a attempt for the study of drug nature of TCM. It also contributed to elucidate the objective authenticity and scientific connotation of Cold and Hot nature of TCM, and express the inherent connection of this nature and the temperature tropism of animal. In this review, a new point and technology platform was provided for establishing an objective method for evaluating the Cold and Hot nature of TCM, which are corresponding with the feature of the application of TCM.

关 键 词：动物行为学 中药寒热药性 动物温度趋向性 中药基础理论 

分 类 号：R285[医药卫生—中药学]