帕洛诺司琼在胃肠癌化疗过程中止吐疗效的观察  

Antiemetic effects of palonosetron in chemotherapy for gastrointestinal tract cancers

作　　者：潘敦[1] 

机构地区：[1]福建医科大学附属第一医院胃肠外科1区,福建福州350004

出　　处：《实用临床医药杂志》2011年第1期86-87,共2页Journal of Clinical Medicine in Practice

摘　　要：目的观察帕洛诺司琼在胃肠癌化疗过程中止吐疗效。方法 120例胃肠癌化疗患者随机分为帕洛诺司琼组、格拉司琼组及恩丹西酮组,每组40例,均于化疗前30 min使用止吐药物,观察比较各组急性呕吐（d1）及迟发性呕吐（d2~d5）的发生情况。结果对于急性呕吐,帕洛诺司琼组的有效率与其他2组比较差异无统计学意义（P〉0.05）。对于迟发性呕吐帕洛诺司琼组的有效率明显高于其他2组,差异有统计学意义（P〈0.05）。结论帕洛诺司琼治疗胃肠癌化疗过程中的呕吐起效快,持续时间长,尤其对迟发性呕吐的治疗效果较好。Objective To observe the antiemetic effects of palonosetron in gastrointestinal tract cancer chemotherapy.Methods 120 patients with gastrointestinal tract cancers were randomly divided into palonosetron group（n=40）,granisetron group（n=40） and ondansetron group（n=40）.Compare the condition of acute vomit（the 1st day）and the late-onset vomit（the 2nd-5th day）.Results For acute vomit,in the palonosetron group,there was no significant difference from the granisetron group and the ondansetron group.For the late-onset vomit,the effective rate of palonosetron group was much higher than that of granisetron group and ondansetron group（P0.05）.Conclusion Palonosetron was a kind of safe,long-acting,efficient antiemetic in gastrointestinal tract cancer chemotherapy.

关 键 词：帕洛诺司琼 化疗 止吐 

分 类 号：R730.5[医药卫生—肿瘤]