Livin在肾癌组织中的表达及意义  

Expression of Livin in renal cell carcinoma and its clinical significance

作　　者：孟强[1] 张晓东[2] 曹丽佳 于新路[1] 杨春明[3] 

机构地区：[1]武警辽宁总队医院泌尿外科,辽宁沈阳110034 [2]武警医学院附属医院肾病科,天津300162 [3]中国医科大学附属第一临床学院泌尿外科,辽宁沈阳110001

出　　处：《武警医学院学报》2011年第3期179-181,F0004,共4页Acta Academiae Medicinae CPAPF

摘　　要：【目的】研究凋亡抑制蛋白Livin在肾癌组织中的表达及其与肿瘤病理分级、临床分期之间的关系。【方法】采用免疫组织化学SP法,检测75例肾癌和10例正常肾组织中Livin的表达情况,并探讨其与肿瘤病理分级、临床分期之间的关系。【结果】Livin在10例正常肾组织中均不表达,而在肾癌组织中的表达率为52%。Livin的表达与肾癌的病理分级无明显相关,而与临床分期显著相关。【结论】凋亡抑制因子Livin和肾癌的发生、进展有关,可以用来作为判断肾癌预后的一项重要指标,并为肾癌的基因治疗提供新的靶点。【Objective】To study the expression of Livin in renal cell carcinoma and its relationship between tissue pathology grade,clinical stage.【Methods】75 renal cell carcinoma and 10 normal renal tissue were used to detect the expression of Livin using immunohistochemistry.【Results】None of all the 10 normal renal tissue samples was detected Livin,whereas,the positive rate was 52% in renal cell carcinoma.The positive rate of Livin was not associated with pathology grade,but associated with clinical stage.【Conclusion】The up-regulated expression of Livin in renal cell carcinoma suggests that Livin plays an important role in tumor occurrence,progression and can serve as marker of prognosis.Livin can provide new target for gene therapy to renal cell carcinoma.

关 键 词：肾癌 LIVIN基因 细胞凋亡 

分 类 号：R737.11[医药卫生—肿瘤]