注射用丁溴东莨菪碱在木糖醇和果糖注射液中的配伍稳定性考察  

Compatible stability of hyoscine butylbromide in xylitol injection and fructose injection

作　　者：谢静 兰晓玉 

机构地区：[1]长沙市第八医院药剂科,长沙410100 [2]柳州市食品药品检验所,广西柳州545001

出　　处：《中南药学》2011年第1期32-35,共4页Central South Pharmacy

摘　　要：目的考察注射用丁溴东莨菪碱在木糖醇注射液和果糖注射液中的配伍稳定性。方法将临床常规剂量注射用丁溴东莨菪碱分别加入木糖醇注射液和果糖注射液中,室温下放置6 h,观察外观,测定pH值及不溶性微粒数,并采用高效液相色谱法测定配伍后不同时间点溶液中丁溴东莨菪碱含量。结果 6 h内2种配伍液的外观、pH值及丁溴东莨菪碱含量无明显改变,不溶微粒数符合中国药典规定。结论注射用丁溴东莨菪碱可以与木糖醇注射液和果糖注射液配伍使用。Objective To investigate the compatible stability of hyoscine butylbromide in xylitol injection and fructose injection respectively.Methods A clinical routine dose of hyoscine butylbromide was added to xylitol injection or fructose injection and the mixtures were kept at room temperature respectively.High-performance liquid chromatography was used to determine the content of hyoscine butylbromide in the fluid at 0,1,2,3,4 and 6 h after the preparation.The appearance,pH value and insoluble particles were observed.Results No remarkable changes in the appearance,pH value and contents were observed in xylitol injection and fructose injection at room temperature,while the insoluble particles varied slightly in an acceptable range.Conclusion Hyoscine butylbromide can be mixed with xylitol injection or fructose injection in clinical practice.

关 键 词：丁溴东莨菪碱 木糖醇 果糖 配伍 稳定性 高效液相色谱 

分 类 号：R927.2[医药卫生—药学]