基质金属蛋白酶-7和E-钙黏附素在胃癌组织中的表达及其相关性  

Expression and relationship between matrix metalloproteinase-7 and E-cadherin in gastric cancer

作　　者：董荣坤[1] 张笃[1] 黄建朋[1] 韩明福[1] 汪启斌[1] 付俊[1] 王琳[1] 

机构地区：[1]湖北医药学院附属人民医院胃肠外科,湖北十堰442000

出　　处：《肿瘤研究与临床》2011年第1期25-27,共3页Cancer Research and Clinic

基　　金：湖北省十堰市科技局重点科研项目（2008-28-12）

摘　　要：目的探讨基质金属蛋白酶．7（MMP．7）、E-钙黏附素（E—CD）在胃癌组织中的表达及其与胃癌侵袭、转移的相关性。方法采用原位杂交法，检测78例胃癌组织中MMP-7mRNA和E—CDmRNA的表达，观察二者与浸润深度和淋巴结转移之间的关系。结果胃癌组织中MMP-7mRNA和E-CDmRNA的阳性表达与浸润深度和淋巴结转移有关。MMP-7mRNA阳性表达的胃癌组织中E—CDmRNA的阳性表达率[9．09％（6／66）[低于MMP-7mRNA阴性表达的胃癌组织中E—CDmRNA的阳性表达率[66．70％（8／12）1，二者呈负相关（r=-0．269，P〈0．05）。结论MMP-7mRNA和E—CDmRNA的表达与胃癌的浸润、转移密切相关，且二者的表达呈负相关。检测MMP-7mRNA和E—CDmRNA在胃癌患者胃镜活检组织中的表达有助于预后判断。Objective To evaluate the expressions of MMP-7, E-cadherin in gastric carcinoma, and their relationship with tumor cell invasion and metastasis. Methods The MMP-7 mRNA and E-CD mRNA were detected by hybridization in situ in 78 gastric cancer tissues. Then analyze the relationship between the expression of MMP-7, E-CD and clinicopathological features. Results The expressions of MMP-7 and E- cadheriu were significantly related with the invasion and metastasis of gastric cancer cell. The E-CD mRNA expression rate in MMP-7 mRNA positive gastric carcinoma tissue was much lower than that in negative carcinoma tissue （9.09 % vs 66.70 %）. Conclusion Expression of MMP-7 mRNA and E-CD mRNA is associated with invasion, metastasis. Detection of MMP-7 mRNA and E-CD mRNA in bioptic specimens may be helpful in predicting tumor metastatic and recurrent potential and prognosis for patients with gastric carcinoma.

关 键 词：胃肿瘤 基质金属蛋白酶-7 E-钙黏着糖蛋白类 肿瘤侵袭 肿瘤转移 

分 类 号：R735.2[医药卫生—肿瘤]