C—erbB-2在结直肠癌中的表达及其临床意义  

Expression and clinical significance of C-erbB-2 in colorectal carcinoma

作　　者：李清国[1] 汪长健[2] 颜士岩[3] 史恩溢[3] 陆洪芬[3] 赵广法[2] 

机构地区：[1]江苏省苏北人民医院普外科,扬州225001 [2]复旦大学附属肿瘤医院腹部外科 [3]复旦大学附属肿瘤医院病理科

出　　处：《肿瘤研究与临床》2011年第1期31-33,共3页Cancer Research and Clinic

摘　　要：目的探讨C—erbB-2在结直肠癌中的表达及临床意义。方法运用免疫组织化学EnVision两步法检测171例结直肠癌中C—erbB-2的表达情况，并取15例正常结直肠组织行对照研究。结果C．erbB-2在结直肠癌肿瘤组织中阳性率为23．4％（40／171），在正常结直肠组织中无表达，两者差异具有统计学意义（P〈0．05）。结直肠癌中细胞膜C—erbB-2强阳性表达（＋＋和＋＋＋）5例（2．92％）。C—erbB-2的表达与患者性别、肿瘤部位、大小、分化程度、浸润深度、脉管内癌栓及神经侵犯等临床病理指标无明显相关性（P〉0．05）。C—erbB-2阴性表达的患者5年生存率为69．5％（91／131），阳性表达患者为65．0％（26／40），两者差异无统计学意义（P〉0．05）。结论在结直肠癌中，C—erbB-2表达与临床病理指标间无相关性，其在判断预后方面无重要意义。Objective To investigate the expression of oncogene C-erbB-2 and its significance in colorectal carcinoma. Methods Immunohistological EnVision staining was used to detect the expression of C-erbB-2 in 171 colorectal carcinoma, and 15 normal colorectal tissues were taken as controls. Results The positive percentages of C-erbB-2 in colorectal carcinoma and normal colorectal tissues were 23.4 % （40/171） and O, which was significantly different （P 〈0.05）. Only 5 samples showed strong positive expression （＋＋ and ＋＋＋） on epicyte, no relationship was found between C-erbB-2 expression and patients~ gender, tumor differentiation, tumor stage, vascular and lymph node involvement, etc（P 〉0.05）. The five year survival rate were 69.5 % （91/131） and 65.0 % （26/40） of C-erbB-2 negative and positive expression, the difference was not statistical （P 〉0.05）. Conclusion There was on significant association between C-erbB-2 expression and clinicopathologic characteristics of colorectal carcinoma. C-erbB-2 did not present prognostic value in colorectal carcinoma.

关 键 词：结直肠肿瘤 基因 ERBB-2 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]